{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:19:36Z","timestamp":1792300776920,"version":"4.4.0"},"reference-count":89,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T00:00:00Z","timestamp":1407974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To review recent biomolecular advances in etiopathogenesis of acquired cholesteatoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>MEDLINE via OVID (to March 2014) and PubMed (to March 2014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>All articles referring to etiopathogenesis of acquired cholesteatoma were identified in the above databases, from which 89 articles were included in this review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mechanisms underlying the etiopathogenesis of acquired cholesteatoma remain a subject of competing hypotheses. Four theories dominate the debate, including theories of invagination, immigration, squamous metaplasia, and basal cell hyperplasia. However, no single theory has been able to explain the clinical characteristics of all cholesteatoma types: uncoordinated hyperproliferation, invasion, migration, altered differentiation, aggressiveness, and recidivism. Modern technologies have prompted a number of researchers to seek explanations at the molecular level. First, cholesteatomas could be considered an example of uncontrolled cell growth, capable of altering the balance toward cellular hyperproliferation and enhancing the capacity for invasion and osteolysis. Second, the dysregulation of cell growth control involves internal genomic or epigenetic alterations and external stimuli, which induce excessive host immune response to inflammatory and infectious processes. This comprises several complex and dynamic pathophysiologic changes that involve extracellular and intracellular signal transduction cascades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This article summarizes the existing theories and provides conceptual insights into the etiopathogenesis of acquired cholesteatoma, with the aim of stimulating continued efforts to develop a nonsurgical means of treating the disorder. <jats:italic>Laryngoscope<\/jats:italic>, 125:234\u2013240, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24890","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T08:17:43Z","timestamp":1408004263000},"page":"234-240","source":"Crossref","is-referenced-by-count":129,"title":["Etiopathogenesis of acquired cholesteatoma: Prominent theories and recent advances in biomolecular research"],"prefix":"10.1002","volume":"125","author":[{"given":"Chin\u2010Lung","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Taipei Veterans General Hospital"},{"name":"Department of Otolaryngology, National Yang\u2010Ming University School of Medicine; Institute of Brain Science National Yang\u2010Ming University"},{"name":"Department of Otolaryngology National Defense Medical Center, Taipei Taiwan R.O.C."},{"name":"Department of Otolaryngology Taoyuan Armed Forces General Hospital, Taoyuan Taiwan R.O.C"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2006.08.003"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70517-4"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01583540"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487809124763"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988409200313"},{"key":"e_1_2_13_7_1","first-page":"5","article-title":"Mastoid volume and eustachian tube function in ears with cholesteatoma","volume":"8","author":"Lindeman P","year":"1987","journal-title":"Am J Otol"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947108000312"},{"key":"e_1_2_13_9_1","first-page":"786","article-title":"Pathogenesis of attic cholesteatoma: clinical and immunohistochemical support for combination of retraction theory and proliferation theory","volume":"21","author":"Sudhoff H","year":"2000","journal-title":"Am J Otol"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1988.01860240078028"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02104525"},{"key":"e_1_2_13_12_1","first-page":"5","article-title":"Cholesteatom, Perforation derMembrana flaccida Shrapnelli und Tubenverschluss","volume":"20","author":"Bezold F","year":"1890","journal-title":"Zeitschrift fuer Ohrenheilkunde"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31823c919c"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487809124722"},{"key":"e_1_2_13_15_1","first-page":"428","article-title":"Desquamative entundung des mittelohrs (Cholesteatom des Felsenbeins)","volume":"14","author":"Wendt H","year":"1873","journal-title":"Arch Heilkunde"},{"key":"e_1_2_13_16_1","first-page":"769","article-title":"The chronic ear. 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