{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:51:09Z","timestamp":1790520669436,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate the effect of oral prednisolone on recovery from tonsillectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, randomized, controlled trial of 198 consecutive patients, aged 4 years and older, with no previous or known contraindications to steroid therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All 198 patients scheduled for elective tonsillectomy with or without adenoidectomy from April 2013 to April 2014 were included. The participants were then randomly assigned to receive a postoperative course of prednisolone 0.25 mg\/kg\/d or no prednisolone over 7 days. During the first postoperative day, pain, type of diet (none, fluid, soft, normal), type of activity (none, bed rest, quiet, restricted, normal), presence of nausea and vomiting, postoperative bleeding rate, and sleep disturbance were assessed using questionnaires. All patients were followed up on days 7 and 14 by endoscopic photographic examination of both tonsillar fossa and by completion of questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant differences in pain, diet, activity, rate of minor bleeding, nausea\/vomiting, fever, or sleep disturbance were observed between the groups on day 1. On day 7, however, in pediatric patients, differences in pain (<jats:italic>P<\/jats:italic>\u2009=\u2009.001), diet (<jats:italic>P<\/jats:italic>\u2009=\u2009.001), activity (<jats:italic>P<\/jats:italic>\u2009=\u2009.004), mean area of re\u2010epithelialization (<jats:italic>P<\/jats:italic>\u2009=\u2009.000), fever (<jats:italic>P<\/jats:italic>\u2009=\u2009.04), and sleep disturbance (<jats:italic>P<\/jats:italic>\u2009=\u2009.04) were observed. On day 14, differences in the mean area of re\u2010epithelialization (<jats:italic>P<\/jats:italic>\u2009=\u2009.000, .001) remained in both pediatric and adult patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral prednisolone may be beneficial during recovery from tonsillectomy without causing any serious complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1b. <jats:italic>Laryngoscope<\/jats:italic>, 125:111\u2013117, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24958","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T13:27:08Z","timestamp":1412688428000},"page":"111-117","source":"Crossref","is-referenced-by-count":34,"title":["Effects of oral prednisolone on recovery after tonsillectomy"],"prefix":"10.1002","volume":"125","author":[{"given":"Soo K.","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungbuk National University College of Medicine Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungbuk National University College of Medicine Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungbuk National University College of Medicine Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je Y.","family":"Yeon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungbuk National University College of Medicine Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo S.","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungbuk National University College of Medicine Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Chungbuk National University College of Medicine Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0882-5963(97)80075-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200110000-00008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.111354"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200012000-00003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812447776"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00314-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.11.036"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.99428"},{"key":"e_1_2_6_10_1","first-page":"CD003997","article-title":"Steroids for improving recovery following tonsillectomy in children","volume":"10","author":"Steward DL","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_11_1","first-page":"144","article-title":"How to make tonsillectomy a safer procedure: the anaesthetist's view","volume":"75","author":"Czarnetzki C","year":"2013","journal-title":"ORL J Otolaryngol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197202000-00016"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2002.00588.x"},{"key":"e_1_2_6_14_1","first-page":"185","volume-title":"Instructional Courses","author":"Hawkins DB","year":"1991"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1990.01870020062016"},{"key":"e_1_2_6_16_1","first-page":"1139","article-title":"Complication of tonsillectomy and adenoidectomy in 9409 children observed overnight","volume":"135","author":"Crysdale WS","year":"1986","journal-title":"Can Med Assoc J"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198704000-00004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100131767"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.24958","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.24958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:44:46Z","timestamp":1696358686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.24958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,7]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/lary.24958"],"URL":"https:\/\/doi.org\/10.1002\/lary.24958","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,7]]}}}