{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:07:26Z","timestamp":1785175646412,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T00:00:00Z","timestamp":1414368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To investigate the clinical significance of three\u2010dimensional\u2010fluid\u2010attenuated inversion recovery (3D\u2010FLAIR) magnetic resonance imaging (MRI) findings in patients with Ramsay\u2010Hunt syndrome (RHS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 28 consecutive patients of RHS with temporal bone MRI. Initial clinical findings and outcome were assessed by House\u2010Brackmann (HB) scales, electroneuronography (ENoG), and pure tone audiometry (PTA). Two radiologists evaluated the presence of abnormalities on pre\u2010\/postcontrast 3D\u2010FLAIR for the cranial nerve (CN)\u2010VII, CN\u2010VIII, inner ear (IE), and the posterior fossa by consensus. The relative signal intensity and enhancement degree (rED) of the structures were measured using ImageJ (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/rsbweb.nih.gov\/ij\/\">http:\/\/rsbweb.nih.gov\/ij\/<\/jats:ext-link>). Statistical test correlated the clinical symptoms and the outcome with the analysis results of 3D\u2010FLAIR images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>3D\u2010FLAIR demonstrated enhancement of CN\u2010VII in all patients. Precontrast hyperintensity and enhancement were seen in eight and 16 patients with IE, and in four and six with CN\u2010VIII, respectively. Precontrast hyperintensity of IE or CN\u2010VIII was significantly associated with the presence of vertigo (<jats:italic>P<\/jats:italic> value\u2009&lt;\u20090.05). Precontrast hyperintensity of IE or CN\u2010VIII significantly correlated with clinical symptoms assessed by HB, ENoG, and PTA (<jats:italic>P<\/jats:italic> value\u2009&lt;\u20090.05, respectively). rED of the vestibule moderately correlated with initial HB scale (<jats:italic>r<\/jats:italic>\u2009=\u20090.391, <jats:italic>P<\/jats:italic>\u2009=\u20090.039). There was no correlation between any of the 3D\u2010FLAIR findings and the follow\u2010up HB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RHS shows frequent abnormalities of IE or CN\u2010VIII, as well as CN\u2010VII on pre\u2010\/postcontrast 3D\u2010FLAIR images. Precontrast hyperintensity of IE\/CN\u2010VIII on 3D\u2010FLAIR is significantly correlated with the severity of facial palsy, the presence of vertigo, and the degree of hearing impairment but not with clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 125:950\u2013955, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.24973","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T07:58:47Z","timestamp":1414396727000},"page":"950-955","source":"Crossref","is-referenced-by-count":24,"title":["The clinical significance of findings obtained on 3<scp>D<\/scp>\u2010<scp>FLAIR MR<\/scp> imaging in patients with <scp>R<\/scp>amsay\u2010<scp>H<\/scp>unt syndrome"],"prefix":"10.1002","volume":"125","author":[{"given":"Mi S.","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, Asan Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, Asan Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, Asan Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Min","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Ulsan College of Medicine, Asan Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong H.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Ulsan College of Medicine, Asan Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu S.","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, Asan Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young J.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, Asan Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra G.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, Asan Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung H.","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, Asan Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2011.10.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21108"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100111971"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2010.520167"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489409128326"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489309126181"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100131305"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-67-800-819"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199305000-00033"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-68-807-334"},{"key":"e_1_2_7_12_1","first-page":"154","article-title":"Correlation 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