{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:29:51Z","timestamp":1787869791526,"version":"build-2784847793"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T00:00:00Z","timestamp":1415232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Definitive tissue diagnosis for lesions warranting biopsy is shifting from the operating room to the office. Safety, tolerance, factors related to successful biopsy, and time to treatment are not well\u2010defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of 116 patients undergoing in\u2010office biopsy of oropharynx, larynx, or hypopharynx were included. Logistic regression determined if demographics, site, T\u2010stage, or approach (transoral\/transnasal) were related to success. Time to definitive treatment was also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two transnasal and 24 transoral biopsies were performed on 73 laryngeal, 35 oropharyngeal, and 8 hypopharyngeal lesions. Of those, 97 of 116 diagnoses were made in\u2010office. There were no complications; two patients did not tolerate the procedure. Success was not related to age (<jats:italic>P<\/jats:italic>\u2009=\u20090.374), site (<jats:italic>P<\/jats:italic>\u2009=\u20090.527), T\u2010stage (<jats:italic>P<\/jats:italic>\u2009=\u20090.587), or approach (<jats:italic>P<\/jats:italic>\u2009=\u20090.566). Time to treatment was 24.2\u2009\u00b1\u200913.9 days with successful office biopsy and 48.8\u2009\u00b1\u200949.4 days without.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High procedural completion rate was observed across patients, sites, and approaches. All patients should be considered for in\u2010office biopsy, a more time\u2010 and cost\u2010effective option leading to earlier treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 125:919\u2013923, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25007","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T11:24:33Z","timestamp":1415273073000},"page":"919-923","source":"Crossref","is-referenced-by-count":57,"title":["In\u2010office biopsy of upper airway lesions: Safety, tolerance, and effect on time to treatment"],"prefix":"10.1002","volume":"125","author":[{"given":"Dylan","family":"Lippert","sequence":"first","affiliation":[{"name":"University of Wisconsin\u2013Madison School of Medicine and Public Health Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery Madison Wisconsin U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2013Madison School of Medicine and Public Health Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery Madison Wisconsin U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phat","family":"Dang","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2013Madison School of Medicine and Public Health Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery Madison Wisconsin U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"McCulloch","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2013Madison School of Medicine and Public Health Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery Madison Wisconsin U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory K.","family":"Hartig","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2013Madison School of Medicine and Public Health Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery Madison Wisconsin U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth H.","family":"Dailey","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2013Madison School of Medicine and Public Health Department of Surgery Division of Otolaryngology\u2013Head and Neck Surgery Madison Wisconsin U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_6_3_1","volume-title":"Cancer Facts and Figures, 2007","author":"American Cancer Society","year":"2007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.01.016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2011.10.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.38"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.11.034"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.05.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199503001-00001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)02049-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02606-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.07.720"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.04.001"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25007","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:40:55Z","timestamp":1696401655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,6]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1002\/lary.25007"],"URL":"https:\/\/doi.org\/10.1002\/lary.25007","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,6]]}}}