{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:23:55Z","timestamp":1789683835156,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Preoperative localization of sentinel lymph nodes in head and neck cutaneous malignancies can be aided by single\u2010photon emission computed tomography\/computed tomography (SPECT\/CT); however, its true predictive value for identifying lymph nodes intraoperatively remains unquantified. This study aims to understand the sensitivity, specificity, and positive and negative predictive values of SPECT\/CT in sentinel lymph node biopsy for cutaneous malignancies of the head and neck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Blinded retrospective imaging review with comparison to intraoperative gamma probe confirmed sentinel lymph nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A consecutive series of patients with a head and neck cutaneous malignancy underwent preoperative SPECT\/CT followed by sentinel lymph node biopsy with a gamma probe. Two nuclear medicine physicians, blinded to clinical data, independently reviewed each SPECT\/CT. Activity within radiographically defined nodal basins was recorded and compared to intraoperative gamma probe findings. Sensitivity, specificity, and negative and positive predictive values were calculated with subgroup stratification by primary tumor site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two imaging reads were performed on 47 patients with cutaneous malignancy who underwent SPECT\/CT followed by sentinel lymph node biopsy. Overall sensitivity was 73%, specificity 92%, positive predictive value 54%, and negative predictive value 96%. The predictive ability of SPECT\/CT to identify the basin or an adjacent basin containing the single hottest node was 92%. SPECT\/CT overestimated uptake by an average of one nodal basin. In the head and neck, SPECT\/CT has higher reliability for primary lesions of the eyelid, scalp, and cheek.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SPECT\/CT has high sensitivity, specificity, and negative predictive value, but may overestimate relevant nodal basins in sentinel lymph node biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 125:877\u2013882, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25024","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T08:30:30Z","timestamp":1415781030000},"page":"877-882","source":"Crossref","is-referenced-by-count":12,"title":["The predictive value of single\u2010photon emission computed tomography\/computed tomography for sentinel lymph node localization in head and neck cutaneous malignancy"],"prefix":"10.1002","volume":"125","author":[{"given":"Aaron K.","family":"Remenschneider","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts"},{"name":"Department of Otology and Laryngology Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda E.","family":"Dilger","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts"},{"name":"Department of Otology and Laryngology Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Nuclear Medicine &amp; Molecular Imaging Massachusetts General Hospital, Harvard Medical School Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin L.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Nuclear Medicine &amp; Molecular Imaging Massachusetts General Hospital, Harvard Medical School Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Nuclear Medicine &amp; Molecular Imaging Massachusetts General Hospital, Harvard Medical School Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin S.","family":"Emerick","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts"},{"name":"Department of Otology and Laryngology Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26288"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060992"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420040034005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2009.03.003"},{"key":"e_1_2_6_6_1","first-page":"1356","article-title":"Imaging of malignant bone involvement by morphologic, scintigraphic, and hybrid modalities","volume":"46","author":"Even\u2010Sapir E","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.232025103"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01885.x"},{"key":"e_1_2_6_9_1","first-page":"323","article-title":"Octreo\u2010SPECT\/CT imaging for accurate detection and localization of suspected neuroendocrine tumors","volume":"52","author":"Perri M","year":"2008","journal-title":"Q J Nucl Med Mol Imaging"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2011.11.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/2012.jama.11030"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0339-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0632-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2004.05.008"},{"key":"e_1_2_6_15_1","first-page":"1413","article-title":"Lymphoscintigraphy for sentinel node mapping using a hybrid SPECT\/CT system","volume":"44","author":"Even\u2010Sapir E","year":"2003","journal-title":"J Nucl Med"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21392"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e3282ef415b"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.174.3.1740837"},{"key":"e_1_2_6_19_1","volume-title":"Pocket Guide to Neck Dissection Classification and TNM Staging of Head and Neck Cancer","author":"Deschler DG","year":"2008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(01)00847-X"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-001-0538-y"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.08.004"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22964"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.02.015"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21865"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25024","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:41:12Z","timestamp":1696401672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,12]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1002\/lary.25024"],"URL":"https:\/\/doi.org\/10.1002\/lary.25024","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,12]]}}}