{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:46:15Z","timestamp":1787730375244,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>Deliberate hypotension, reverse Trendelenburg position, and hyperventilation are techniques utilized during functional endoscopic sinus surgery to attempt to reduce surgical bleeding. These methods may predispose patients to cerebral ischemia. Cerebral oximetry has not been investigated extensively within otolaryngologic surgery. Our study sought to address the question of whether cerebral oximetry is feasible in the FESS population and evaluate whether the data provided may be useful in the assessment of cerebral perfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective, blinded, observational trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We designed a prospective, blinded, observational trial of patients undergoing functional endoscopic sinus surgery using cerebral oximetry monitoring. Collected data included mean arterial blood pressure (MAP), end\u2010tidal carbon dioxide (EtCO\n                      <jats:sub>2<\/jats:sub>\n                      ), cerebral saturation (SctO\n                      <jats:sub>2<\/jats:sub>\n                      ), postanesthesia care unit (PACU) length of stay, and incidence of postoperative nausea and vomiting (PONV).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010one subjects were enrolled into the study. Univariate analyses showed cross\u2010correlation between concurrent EtCO\n                      <jats:sub>2<\/jats:sub>\n                      values and SctO\n                      <jats:sub>2<\/jats:sub>\n                      of 0.43 (95% CI: 0.27 to 0.59) and between present EtCO\n                      <jats:sub>2<\/jats:sub>\n                      and the SctO\n                      <jats:sub>2<\/jats:sub>\n                      5 minutes later of 0.46 (95% CI: 0.33 to 0.59). MAP was not significantly cross\u2010correlated with SctO\n                      <jats:sub>2<\/jats:sub>\n                      . Patients who had an SctO\n                      <jats:sub>2<\/jats:sub>\n                      below 60% at any time had a median (interquartile range [IQR]) PACU length of stay of 167 (IQR, 95\u2013386) minutes. Patients whose cerebral saturation did not fall below 60% at any time had a median PACU length of stay of 103 (IQR, 76\u2013155) minutes. This difference did not reach statistical significance (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.257). The median (IQR) maximum decline in SctO\n                      <jats:sub>2<\/jats:sub>\n                      for patients with PONV was 11.2% (IQR, 8.2%\u201313.1%) and for patients without PONV was 7.1% (IQR, 5.1%\u20139.8%) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.126).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Cerebral oximetry monitoring was feasible during functional endoscopic sinus surgery. This study demonstrated a cross\u2010correlation between EtCO\n                      <jats:sub>2<\/jats:sub>\n                      and SctO\n                      <jats:sub>2<\/jats:sub>\n                      , but not MAP and SctO\n                      <jats:sub>2<\/jats:sub>\n                      . A longer PACU length of stay and higher rate of PONV were seen but did not reach statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      2b\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 125:E127\u2013E131, 2015\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.25027","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T03:29:21Z","timestamp":1415762961000},"source":"Crossref","is-referenced-by-count":16,"title":["Cerebral oximetry monitoring during sinus endoscopy"],"prefix":"10.1002","volume":"125","author":[{"given":"Joshua A.","family":"Heller","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Samuel","family":"DeMaria","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Govindaraj","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Mo","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Health Evidence and Policy Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menachem M.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Danger points, complications and medico\u2010legal aspects in endoscopic sinus surgery","volume":"12","author":"Hosemann W","year":"2013","journal-title":"GMS Curr Top Otorhinolaryngol Head Neck 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