{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:23:28Z","timestamp":1778174608641,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>The efficacy of macrolides in chronic rhinosinusitis (CRS) is still under controversy. To date, only two double\u2010blind, placebo\u2010controlled studies have been published with differing results. None of these studies investigated the possible benefit of macrolides in the postoperative period. We conducted an investigator\u2010initiated clinical trial using 250\u2010mg erythromycin once a day over a period of 3 months, beginning the administration of either erythromycin or placebo 2 weeks after a surgical intervention for CRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Randomized double\u2010blind, placebo\u2010controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The concentrations of eosinophilic cationic protein (ECP) and myeloperoxidase in nasal secretion were chosen as primary outcome measures. Additionally, as a secondary outcome measure, changes in the Sino\u2010Nasal Outcome Test\u201020 score, olfaction, saccharin transit time, nasal endoscopy score, and self\u2010rating of nasal health using a visual analogue scale were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010seven patients after surgery for CRS with or without nasal polyps were screened, and 58 patients were randomized to the study groups. For the primary outcomes, the concentrations of ECP changed from 176.4 \u00b5l\/l\u2009\u00b1\u200979.0 to 226.1 \u00b5l\/l\u2009\u00b1\u2009200.6 in the erythromycin group and from 186.9 \u00b5l\/l\u2009\u00b1\u200936.0 to 192.9 \u00b5l\/l\u2009\u00b1\u2009189.2 in the placebo group; no statistical differences were found. Of the secondary outcomes, only the nasal endoscopy score showed a statistically significant improvement in the erythromycin group (from 2.6\u2009\u00b1\u20091.4 to 1.9\u2009\u00b1\u20091.5 points) compared to the placebo group (from 2.5\u2009\u00b1\u20091.3 to 2.6\u2009\u00b1\u20091.5 points). The subgroup of patients without nasal polyps in the erythromycin group showed a tendency to improvement in some secondary outcome criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A general recommendation for long\u2010term, low\u2010dose erythromycin treatment after surgery for CRS cannot be given. In patients with CRS without nasal polyps, a tendency to improved parameters was detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      Ib.\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 125:1048\u20131055, 2015\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.25052","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T15:05:15Z","timestamp":1416927915000},"page":"1048-1055","source":"Crossref","is-referenced-by-count":45,"title":["Controlled trial for long\u2010term low\u2010dose erythromycin after sinus surgery for chronic rhinosinusitis"],"prefix":"10.1002","volume":"125","author":[{"given":"Boris R.","family":"Haxel","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery AMEOS Klinikum Haldensleben Haldensleben Germany"},{"name":"Department of Otorhinolaryngology Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meike","family":"Clemens","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niki","family":"Karaiskaki","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Dippold","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisanne","family":"Kettern","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf J.","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_6_3_1","first-page":"163","article-title":"Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis","volume":"20","author":"Bachert C","year":"2007","journal-title":"Clin Allergy 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A summary for otorhinolaryngologists","volume":"45","author":"Fokkens W","year":"2007","journal-title":"Rhinology"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812470427"},{"key":"e_1_2_6_22_1","first-page":"197","article-title":"A comparing study of clarithromycin XL with co\u2010amoxiclav for treatment of chronic sinusitis; a clinical trial","volume":"4","author":"Amini M","year":"2009","journal-title":"Iranian Journal of Clinical Infectious Diseases"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.02.020"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199910000-00027"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00027"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-013-0416-2"},{"key":"e_1_2_6_27_1","first-page":"259","article-title":"Macrolide therapy of chronic rhinosinusitis","volume":"45","author":"Cervin A","year":"2007","journal-title":"Rhinology"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino11.123"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2012.09.009"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25052","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:10:01Z","timestamp":1696345801000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,25]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/lary.25052"],"URL":"https:\/\/doi.org\/10.1002\/lary.25052","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725248152.793522793","asserted-by":"object"}]},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,25]]}}}