{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:42:35Z","timestamp":1789512155260,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>This study aimed to evaluate the changes in electrocochleography (EcohG) measurements after intratympanic (IT) dexamethasone therapy and to correlate them with the long\u2010term effects on the control of vertigo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective outcomes research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 62 patients with unilateral M\u00e9ni\u00e8re's Disease (MD) refractory to medical therapy for at least 1 year. Each patient was treated with a fixed protocol of three consecutive weekly injections of a commercial 4 mg\/mL dexamethasone preparation. The 1995 American Academy of Otolaryngology\u2013Head and Neck Surgery (AAO\u2013HNS) criteria for reporting treatment outcomes for MD were used.<\/jats:p><jats:p>Electrocochleography (EcohG) measurements were performed 1 month before and 1 and 12 months after IT steroid therapy. Caloric test and vestibular evoked myogenic potential (VEMPs) were performed before the IT treatment. The summating potential\/action potential (SP\/AP) ratio was measured before and after the IT treatment. A Kaplan\u2010Meier analysis was used to evaluate the control of vertigo over a 2\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete vertigo control (class A) was achieved in 26 patients (41.9%) at the 12\u2010month follow\u2010up and in 12 patients (19.3%) at the 24\u2010month follow\u2010up. A significant reduction (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) in the SP\/AP ratio after the IT steroid treatment was observed in the first\u2010month determination, but no significant differences were found when the initial and 12\u2010month determination were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IT dexamethasone provides an alternative treatment for patients with M\u00e9ni\u00e8re's Disease. A transitory reduction of the endolymphatic hydrops is detected by the EcohG 1 month after treatment. The hydrops levels returned to their initial values in the 1\u2010year EcohG follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b. <jats:italic>Laryngoscope<\/jats:italic>, 125:1183\u20131188, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25057","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T16:38:48Z","timestamp":1417192728000},"page":"1183-1188","source":"Crossref","is-referenced-by-count":15,"title":["Transitory effect on endolymphatic hydrops of the intratympanic steroids for <scp>M<\/scp>\u00e9ni\u00e8re's disease"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-3844","authenticated-orcid":false,"given":"Eduardo","family":"Martin\u2010Sanz","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University Hospital of Getafe Madrid 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