{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:19:11Z","timestamp":1761059951977},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To describe the presentation, treatment, and outcomes of benign fibro\u2010osseous tumors involving the skull base in a pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review from January 2002 to September 2013 of pediatric patients (ages 0\u201318 years) who underwent endoscopic endonasal surgery (EES) for benign fibro\u2010osseous tumors involving the skull base.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen patients were identified with an age range of 2.7 to 17.9 years (mean, 12.5 years). Six juvenile ossifying fibromas, five benign fibro\u2010osseous lesions, two osteomas, and one fibrous dysplasia were treated. Ocular symptoms and nasal obstruction were the most common presenting symptoms in nine (64%) and six (43%) of patients, respectively; five (36%) presented with proptosis and four (29%) with diplopia. Two (14%) patients had cranial nerve VI palsy. Transsellar and transclival approaches were used in five (36%) of patients. Orbital and optic nerve decompressions were the most common components of the approaches performed in nine (64%) of the surgeries. Gross total resection (GTR) was achieved with single\u2010stage surgery in 10 (71%) patients; two additional patients underwent staged GTR. Two intraoperative cerebrospinal fluid (CSF) leaks occurred and were repaired endoscopically. There were no postoperative CSF leaks or infectious complications. Two patients had transient diplopia, and two had transient diabetes insipidus, all of which resolved. The mean follow\u2010up was 13.8 months. Two patients had a recurrence, and both required additional EES achieving GTR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EES for benign fibro\u2010osseous tumors of the skull base is a safe and effective treatment for excision of these lesions in the pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 125:2199\u20132203, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25070","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T15:59:13Z","timestamp":1435161553000},"page":"2199-2203","source":"Crossref","is-referenced-by-count":19,"title":["Endoscopic endonasal surgery for benign fibro\u2010osseous lesions of the pediatric skull base"],"prefix":"10.1002","volume":"125","author":[{"given":"Amanda L.","family":"Stapleton","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth C.","family":"Tyler\u2010Kabara","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh Medical Center Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center Pittsburgh Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh Medical Center Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center Pittsburgh Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl H.","family":"Snyderman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery"},{"name":"Department of Neurological Surgery University of Pittsburgh Medical Center Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center Pittsburgh Pennsylvania U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"283","volume-title":"World Health Organization Classification of Tumours. 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