{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T15:26:04Z","timestamp":1767108364938},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Parotid gland calcifications can be incidental findings on computed tomography (CT) and have been reported to be associated with chronic inflammatory conditions. Associations between parotid gland calcification and other common medical conditions have not been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following institutional review board approval, 1,571 patients who underwent noncontrast head CT with 1.25\u2010mm slice thickness on a 64\u2010detector row CT between January 2011 and July 2011 were retrospectively reviewed for parotid gland calcifications. Medical records were reviewed for chronic kidney disease, alcoholism, autoimmune conditions, endocrine disorders, elevated alkaline phosphatase, and HIV (human immunodeficiency virus) status. Statistical analyses were performed using Fisher's exact test and multiple logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010three of 1,571 (4%) patients had parotid gland calcifications. Significant associations were observed between parotid gland calcifications and HIV infection (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), chronic kidney disease (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), alcoholism (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), elevated alkaline phosphatase (<jats:italic>P<\/jats:italic>\u2009=\u20090.003), and autoimmune disease (<jats:italic>P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Parotid gland calcifications were associated with HIV, alcoholism, chronic kidney disease, autoimmune disease, and elevated alkaline phosphatase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 125:1360\u20131365, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25095","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T16:15:10Z","timestamp":1418660110000},"page":"1360-1365","source":"Crossref","is-referenced-by-count":14,"title":["Clinical associations of incidentally detected parotid gland calcification on <scp>CT<\/scp>"],"prefix":"10.1002","volume":"125","author":[{"given":"Karen","family":"Buch","sequence":"first","affiliation":[{"name":"Department of Radiology Boston Medical Center, Boston University School of Medicine Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohini N.","family":"Nadgir","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Medical Center, Boston University School of Medicine Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Medical Center, Boston University School of Medicine Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Tannenbaum","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Medical Center, Boston University School of Medicine Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Al","family":"Ozonoff","sequence":"additional","affiliation":[{"name":"Biostatistics Core, Clinical Research Program Children's Hospital Boston, Harvard Medical School Boston Massachusetts U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Medical Center, Boston University School of Medicine Boston Massachusetts U.S.A"},{"name":"Department of Radiation Oncology Boston Medical Center, Boston University School of Medicine Boston Massachusetts U.S.A"},{"name":"; 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