{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T16:42:05Z","timestamp":1774370525153,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T00:00:00Z","timestamp":1419638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To determine the effect of topical intranasal oxymetazoline on nasal resistance and aerobic exercise performance in patients with nasal congestion caused by inferior turbinate hypertrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Individual randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight patients with inferior turbinate hypertrophy performed a set of exercise tests to exhaustion 1 week apart. They were given oxymetazoline or a placebo before each of the two test sessions according to a random pattern. Changes in nasal airflow were measured as peak nasal flow and ventilatory efficiency parameters, ventilatory equivalents, end\u2010expiratory pressure, oxygen consumption, cardiac efficiency, rate of perceived exertion, and maximal and submaximal mechanical power.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten minutes after use of the drug or placebo, improvements in maximum nasal airflow were seen in the oxymetazoline group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). However, exercise tests showed improvements in both groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). After exertion, there was no difference between the two groups in maximum nasal airflow (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). There were no differences between groups in oxygen consumption, rate of perceived exertion, respiratory exchange ratio, ventilation, or ventilatory equivalents for oxygen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oxymetazoline increased nasal airflow in patients with turbinate hypertrophy, but this change did not translate into gains in physical exercise parameters or perceived exertion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1b. <jats:italic>Laryngoscope<\/jats:italic>, 125:1301\u20131306, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25107","type":"journal-article","created":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T07:38:21Z","timestamp":1419665901000},"page":"1301-1306","source":"Crossref","is-referenced-by-count":8,"title":["Effects of oxymetazoline on nasal flow and maximum aerobic exercise performance in patients with inferior turbinate hypertrophy"],"prefix":"10.1002","volume":"125","author":[{"given":"Javier","family":"G\u00f3mez\u2010Herv\u00e1s","sequence":"first","affiliation":[{"name":"Servicio de Otorrinolaringolog\u00eda Hospital Universitario San Cecilio de Granada"},{"name":"Servicio de Otorrinolaringolog\u00eda Hospital La Inmaculada, Hu\u00e9rcal\u2010Overa, Almer\u00eda Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Garc\u00eda\u2010Valdecasas Bernal","sequence":"additional","affiliation":[{"name":"Servicio de Otorrinolaringolog\u00eda Hospital Universitario San Cecilio de Granada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Fern\u00e1ndez\u2010Prada","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica Medicina Preventiva, Vigilancia y Promoci\u00f3n de la Salud, Hospital Universitario San Cecilio de Granada"},{"name":"Servicio de Medicina Preventiva y Salud P\u00fablica Hospital Universitario 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