{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:38:10Z","timestamp":1789105090440,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T00:00:00Z","timestamp":1419638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To investigate the influence of posttreatment audiovestibular symptoms, facial neuropathy, and headache on long\u2010term quality\u2010of\u2010life outcomes in patients with sporadic vestibular schwannoma (VS) utilizing the Short Form 36 (SF\u201036) Health Survey and the Penn Acoustic Neuroma Quality of Life (PANQOL) scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional observation study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with sporadic small\u2010 or medium\u2010sized VS (&lt; 3.0 cm) who were evaluated between 1998 and 2008 at two independent tertiary academic referral centers were surveyed. Multivariable associations with the PANQOL total score and the SF\u201036 physical and mental component scores evaluated using regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 538 surveyed patients returned a completed questionnaire, providing a response rate of 79%. Two hundred forty\u2010seven (46%) patients underwent stereotactic radiosurgery, 143 (27%) microsurgery, and 148 (28%) observation. Multivariable regression analysis revealed that ongoing dizziness was associated with the greatest reduction in PANQOL total score, followed by headache. After adjusting for all examined features, ongoing dizziness and ongoing headache were the only two variables that were associated with both the SF\u201036 physical and mental component scores. Patient sex and treatment modality did not significantly influence PANQOL or SF\u201036 scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ongoing dizziness and headache are the strongest predictors of long\u2010term quality\u2010of\u2010life reduction in patients with sporadic VS, while the impact of hearing loss, facial nerve function, and tinnitus are less by comparison. This information may be valuable for patient counseling, refinement of VS quality\u2010of\u2010life assessment instruments, and determining high\u2010yield targets for therapy in efforts to further improve patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 125:1697\u20131702, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25110","type":"journal-article","created":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T07:35:53Z","timestamp":1419665753000},"page":"1697-1702","source":"Crossref","is-referenced-by-count":103,"title":["What drives quality of life in patients with sporadic vestibular schwannoma?"],"prefix":"10.1002","volume":"125","author":[{"given":"Matthew L.","family":"Carlson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic School of Medicine Rochester Minnesota U.S.A"},{"name":"Department of Neurologic Surgery Mayo Clinic School of Medicine Rochester Minnesota U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ystein Vesterli","family":"Tveiten","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Haukeland University Hospital  Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic School of Medicine Rochester Minnesota U.S.A"},{"name":"Department of Neurologic Surgery Mayo Clinic School of Medicine Rochester Minnesota U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik K.","family":"Goplen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Haukeland University Hospital  Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian 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