{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:32:27Z","timestamp":1783027947583,"version":"3.54.6"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T00:00:00Z","timestamp":1419638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective\/Hypothesis<\/jats:title><jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) and extranodal natural killer\/T\u2010cell lymphoma (ENKTL) are aggressive tumors. ENTKL is very rare in the United States and often affects the nasal cavity and paranasal sinuses; DLBCL, although more common, rarely occurs in these locations. Our study aims to compare incidence and survival of these lymphomas in the sinonasal cavity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective analysis of the United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The SEER database was searched for patients diagnosed with sinonasal ENKTL and DLBCL between 1973 and 2011. Data analyzed included patient demographics, incidence, treatment modality, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and twenty\u2010eight sinonasal ENKTL (SN\u2010ENKTL) cases and 1,054 sinonasal DLBCL (SN\u2010DLBCL) cases were identified. The mean ages at diagnosis for SN\u2010ENKTL and SN\u2010DLBCL were 51.7 and 67.8 years, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.0001). Overall 1\u2010, 5\u2010, and 10\u2010year disease\u2010specific survival (DSS) rates for SN\u2010DLBCL were 85.5%, 63.5%, and 44.0%, compared to 66.4%, 30.9%, and 9.2% for SN\u2010ENKTL, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). For patients matched for stage, age, and treatment modality, the 1\u2010, 5\u2010, and 10\u2010year DSS for the SN\u2010DLBCL group was 94.4%, 72.8%, and 46.8%, respectively, whereas the respective survival rates for the SN\u2010ENKTL group were 77.6%, 38.4%, and 13.9%, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 at each time interval).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this study represents the only population\u2010based comparison between SN\u2010DLBCL and SN\u2010ENKTL. SN\u2010DLBCL has a better prognosis regardless of gender, stage, treatment modality, and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b. <jats:italic>Laryngoscope<\/jats:italic>, 125:1077\u20131083, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25111","type":"journal-article","created":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T07:37:11Z","timestamp":1419665831000},"page":"1077-1083","source":"Crossref","is-referenced-by-count":55,"title":["A comparative population\u2010based analysis of sinonasal diffuse large <scp>B<\/scp>\u2010cell and extranodal <scp>NK\/T<\/scp>\u2010cell lymphomas"],"prefix":"10.1002","volume":"125","author":[{"given":"Pariket M.","family":"Dubal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan D.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"},{"name":"Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"},{"name":"Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School Newark New Jersey U.S.A"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2008.03.001"},{"key":"e_1_2_6_3_1","first-page":"338","article-title":"Lymphomas of the head and 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