{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:34:54Z","timestamp":1777620894865,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Image\u2010enhanced endoscopy, such as narrow band imaging and the Storz Professional Image Enhancement System, have been increasingly used in patients with suspect lesions of the larynx and hypopharynx during preoperative and intraoperative assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>In the present study, a contact endoscope was coupled with the systems of image\u2010enhanced endoscopy, as to precisely distinguish the peculiar neoangiogenetic changes in inflammation, and precancerous and cancerous lesions of the larynx and hypopharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010blind study with this original approach of a series of 44 patients with different lesions of the larynx and hypopharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed five obvious vascular patterns matching the diagnosis in 41 patients out of 44, with accuracy in the differential diagnosis between normal tissue and hyperplasia versus mild dysplasia and carcinoma of 97.6%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Enhanced contact endoscopy allows for predicting histologic changes of laryngeal and hypopharyngeal lesions from inflammation to cancer on based on fine evaluation of the neoangiogenetic changes of the chorion. This innovative procedure can be considered an important tool during diagnosis, treatment, and follow\u2010up of patients with precancer and cancer of the larynx and hypopharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1b. <jats:italic>Laryngoscope<\/jats:italic>, 125:1600\u20131606, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25124","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T14:08:47Z","timestamp":1421158127000},"page":"1600-1606","source":"Crossref","is-referenced-by-count":53,"title":["Enhanced contact endoscopy for the detection of neoangiogenesis in tumors of the larynx and hypopharynx"],"prefix":"10.1002","volume":"125","author":[{"given":"Roberto","family":"Puxeddu","sequence":"first","affiliation":[{"name":"Department of Surgery Section of Otorhinolaryngology University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Sionis","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Otorhinolaryngology University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Gerosa","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Pathology University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Carta","sequence":"additional","affiliation":[{"name":"Department of Surgery Section of Otorhinolaryngology University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510012941X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0653-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0251-y"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21565"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509139318"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400501"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/196302"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20732"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007512"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215001906011"},{"key":"e_1_2_6_12_1","first-page":"49","article-title":"Narrow\u2010band imaging: a new tool for evaluation of head and neck squamous cell carcinomas","volume":"28","author":"Piazza C","year":"2008","journal-title":"Review of the literature. 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