{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:14:05Z","timestamp":1772705645538,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To determine the diagnostic value of <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography\u2010computed tomography (PET\u2010CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal metastasis in patients with hypopharyngeal squamous cell carcinoma (SCC) with palpably negative neck and to assess the role of PET\u2010CT as a supplement to CT\/MR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 39 patients with palpably negative neck (36 men and 3 women; average age 65.4 years) underwent tumor resection and neck dissection as primary treatment. All patients were preoperatively evaluated with PET\u2010CT and CT and\/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET\u2010CT, CT\/MR, and a combination of PET\u2010CT and CT\/MR was assessed using histopathologic results as a gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty (51.3%) of the 39 patients were found to have neck metastases. On a level\u2010based analysis, the sensitivity of PET\u2010CT, CT\/MR, and combined interpretation of PET\u2010CT and CT\/MR was 65.7%, 57.1%, and 65.7%, respectively, but without statistical significance. Of the six patients who showed false negative neck findings based on CT\/MR in addition to palpation, four cases were still missed with additional PET\u2010CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The addition of PET\u2010CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal metastasis in patients with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 125:1607\u20131612, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25136","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T11:08:30Z","timestamp":1422616110000},"page":"1607-1612","source":"Crossref","is-referenced-by-count":13,"title":["<sup>18<\/sup><scp>F<\/scp>\u2010<scp>FDG PET<\/scp>\u2010<scp>CT<\/scp> as a supplement to <scp>CT<\/scp>\/<scp>MRI<\/scp> for detection of nodal metastasis in hypopharyngeal <scp>SCC<\/scp> with palpably negative neck"],"prefix":"10.1002","volume":"125","author":[{"given":"Ho\u2010Joon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiology Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinna","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha Young","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Pathology Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Jun","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Woo","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Severance Hospital, Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23221"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000161338.54515.b1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2008.09.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.11.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.12.003"},{"key":"e_1_2_7_7_1","volume-title":"AJCC Cancer Staging Manual","author":"Edge SB","year":"2010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13131470"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.12.032"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.062075"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn125"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2352040134"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3342\/kjorl-hns.2012.55.6.364"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.174.3.1740837"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-1926-6"},{"key":"e_1_2_7_17_1","first-page":"755","article-title":"18F\u2010FDG PET\/CT for detecting nodal metastases in patients with oral cancer staged N0 by clinical examination and CT\/MRI","volume":"47","author":"Schoder H","year":"2006","journal-title":"J Nucl Med"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.7349"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2010.502183"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880310005001"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(00)80121-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-007-0097-9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1054\/jcms.2000.0172"},{"key":"e_1_2_7_24_1","unstructured":"American College of Radiology Imaging Network; National Cancer Institute (NCI). FDG\u2010PET\/CT in assessing the tumor and planning neck surgery in patients with newly diagnosed H&N cancer (ACRIN 6685). In:ClinicalTrials.gov[Internet]. Bethesda MD: National Library of Medicine; 2000. Available at:http:\/\/clinicaltrials.gov\/show\/NCT00983697NLM Identifier: NCT00983697. Cited May 23 2014."}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25136","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:55:51Z","timestamp":1696384551000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/lary.25136"],"URL":"https:\/\/doi.org\/10.1002\/lary.25136","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,30]]}}}