{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:36:35Z","timestamp":1791999395263,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>To investigate the effect of oral plus intranasal corticosteroid (CS) treatment on nasal polyp (NP) mucosa remodeling from patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Case series, retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients (n\u2009=\u200918) with severe CRSwNP were treated with oral prednisone for 2 weeks and intranasal budesonide for 12 weeks. NP biopsies were obtained from patients biopsies before (w0) and after 2 weeks (w2) and 12 weeks (w12) of CS treatment. Matrix metalloprotease 1 (MMP\u20101), MMP\u20102, MMP\u20107, MMP\u20109, and tissue inhibitor of metalloprotease type 1 (TIMP\u20101) expression was evaluated by immunohistochemistry in cell and tissue structures. Epithelial damage, eosinophil infiltration, and collagen content were also examined in NP tissues before and after CS treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to w0: 1) oral plus intranasal CS significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01) increased presence of submucosal glands at w2, decreased epithelial cell hyperplasia at w12, and decreased tissue eosinophilia at w2 and w12; 2) CS treatment significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05) increased immunoreactivity for MMP\u20101 and MMP\u20102 in the epithelium at w2, but decreased immunoreactivity for MMP\u20109 in the epithelium at w2 and w12; 3) at w12, CS significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05) reduced MMP\u20109 immunoreactive positivity and intensity in the extracellular matrix, while increasing total collagen amount in the extracellular matrix; and 4) CS treatment significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01) reduced the number of eosinophils and their MMP and TIMP\u20101 immunoreactive expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CS treatment modulates NP mucosa remodeling, particularly by promoting epithelial repair, regulating tissue remodeling markers, increasing total collagen content, and reducing tissue eosinophil infiltration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      4\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 125:E158\u2013E167, 2015\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.25147","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T09:12:25Z","timestamp":1421140345000},"source":"Crossref","is-referenced-by-count":30,"title":["Corticosteroid treatment regulates mucosal remodeling in chronic rhinosinusitis with nasal polyps"],"prefix":"10.1002","volume":"125","author":[{"given":"Francisco","family":"de Borja Callejas","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Respiratory Immunoallergy August Pi i Sunyer Biomedical Research Institute, University of Barcelona Barcelona Spain"},{"name":"Centers for Biomedical Research Network in Respiratory Diseases Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asunci\u00f3n","family":"Mart\u00ednez\u2010Ant\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Respiratory Immunoallergy August Pi i Sunyer Biomedical Research Institute, University of Barcelona Barcelona Spain"},{"name":"Centers for Biomedical Research Network in Respiratory Diseases Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Picado","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Respiratory Immunoallergy August Pi i Sunyer Biomedical Research Institute, University of Barcelona Barcelona Spain"},{"name":"Pneumology &amp; Allergy Department Hospital Clinic of Barcelona, University of Barcelona Barcelona Spain"},{"name":"Centers for Biomedical Research Network in Respiratory Diseases Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isam","family":"Alobid","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Respiratory Immunoallergy August Pi i Sunyer Biomedical Research Institute, University of Barcelona Barcelona Spain"},{"name":"Rhinology Unit &amp; Smell Clinic ENT Department Hospital Clinic of Barcelona, University of Barcelona Barcelona Spain"},{"name":"Centers for Biomedical Research Network in Respiratory Diseases Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pujols","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Respiratory Immunoallergy August Pi i Sunyer Biomedical Research Institute, University of Barcelona Barcelona Spain"},{"name":"Centers for Biomedical Research Network in Respiratory Diseases Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Valero","sequence":"additional","affiliation":[{"name":"Pneumology &amp; Allergy Department Hospital Clinic of Barcelona, University of Barcelona Barcelona Spain"},{"name":"Centers for Biomedical Research Network in Respiratory Diseases Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Roca\u2010Ferrer","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Respiratory Immunoallergy August Pi i Sunyer Biomedical Research Institute, University of Barcelona Barcelona Spain"},{"name":"Centers for Biomedical Research Network in Respiratory Diseases Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Mullol","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Respiratory Immunoallergy August Pi i Sunyer Biomedical Research Institute, University of Barcelona Barcelona Spain"},{"name":"Rhinology Unit &amp; Smell Clinic ENT Department Hospital Clinic of Barcelona, University of Barcelona Barcelona Spain"},{"name":"Centers for Biomedical Research Network in Respiratory Diseases Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834233ef"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.036"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.07.049"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01226.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32835f80a0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12277"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3282f3f461"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.12.989"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-5-201103010-00011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0247-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12040"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1586"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.106096"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12211"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21462"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3908"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.11.921"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200204000-00026"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-6519(08)75549-3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.04.013"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.02.023"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70091-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02848.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.052"},{"key":"e_1_2_7_28_1","first-page":"173","article-title":"Clinical factors influencing the eosinophil infiltration of nasal polyps","volume":"40","author":"Jankowski R","year":"2002","journal-title":"Rhinology"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3838"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358489"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025590308147"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00364.x"},{"key":"e_1_2_7_33_1","first-page":"615","article-title":"Distribution of matrix metalloproteinases MMP\u20101, MMP\u20102, MMP\u20108 and tissue inhibitor of matrix metalloproteinases\u20102 in nasal polyposis and chronic rhinosinusitis","volume":"26","author":"Eyibilen A","year":"2011","journal-title":"Histol Histopathol"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22363"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00361.2009"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90578.2008"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70379-9"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH771>3.0.CO;2-W"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.04.032"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.17.4.2877"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.02.020"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25147","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:10:10Z","timestamp":1696345810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,13]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/lary.25147"],"URL":"https:\/\/doi.org\/10.1002\/lary.25147","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,13]]}}}