{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:45:42Z","timestamp":1772012742318,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Assess angular vestibular\u2010ocular reflex (VOR) changes after treatment with intratympanic gentamicin (ITG) for M\u00e9ni\u00e8re's disease (MD) and impact on short\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients submitted to ITG for unilateral MD. The gain VOR and the presence of compensatory saccades elicited by rapid head impulses were measured using the video head impulse test (vHIT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 31 subjects (mean age: 59 years). Functional Level Scale (FLS) distributions were 35,5% (FLS3); 32,2% (FLS4); and 32,2% (FLS5). Mean follow\u2010up was 21\u2009\u00b1\u20097 months. Multiple injections were needed in nine patients.<\/jats:p><jats:p>VOR gain in the treated ear was significantly reduced in all subjects and for all the semicircular canals (paired samples <jats:italic>t<\/jats:italic> test; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090,05). Gain averages after treatment were 0,61 (superior); 0,69 (horizontal); and 0,47 (posterior). A horizontal canal VOR gain superior to 0,80 after treatment was associated with the need for a second gentamicin injection (Chi\u2010square; <jats:italic>P<\/jats:italic>\u2009=\u20090,003). Gain asymmetry between the symptomatic and asymptomatic ear (GASM) was increased after treatment. The rate of vestibular function reduction was 47,9%; 26,0%; and 35,8% for the superior, horizontal, and posterior canals, respectively. According to the receiving operator characteristic curve, the amount of change in GASM must be greater than 7 in order to predict the avoidance of a second procedure (area under the curve [AUC] horizontal canal\u2009=\u20090,861) and the amount of vestibular function reduction in the pathologic ear in patients with a controlled disease must be greater than 17,8% (AUC horizontal canal\u2009=\u20090,843).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>When evaluated with the vHIT, intratympanic gentamicin changes in VOR seem to foresee short\u2010term control of vertigo attacks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 125:1915\u20131920, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25156","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T11:00:02Z","timestamp":1422615602000},"page":"1915-1920","source":"Crossref","is-referenced-by-count":28,"title":["Single intratympanic gentamicin injection in <scp>M<\/scp>\u00e9ni\u00e8re's disease: <scp>VOR<\/scp> change and prognostic usefulness"],"prefix":"10.1002","volume":"125","author":[{"given":"Pedro","family":"Marques","sequence":"first","affiliation":[{"name":"Department of Otorhinolarygology\u2013Centro Hospitalar S\u00e3o Jo\u00e3o EPE Porto Portugal"},{"name":"Department of Otorhinolaryngology\u2013University of Oporto Medical School Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Manrique\u2010Huarte","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Cl\u00ednica Universidad de Navarra University of Navarra Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Perez\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Cl\u00ednica Universidad de Navarra University of Navarra Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","volume":"113","author":"Committee on Hearing and Equilibrium guidelines for diagnosing the evaluation of therapy in Meniere's disease. 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