{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:40:58Z","timestamp":1696484458281},"reference-count":8,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>This study investigated the differences between the standard guidelines and the practice patterns of otolaryngologists in managing \u201cpenicillin\u2010allergic\u201d patients. A major goal was to identify factors influencing an otolaryngologist's choice of antibiotic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four hundred seventy members of the American Society of Pediatric Otolaryngologists (ASPO) and 150 general otolaryngologists from the Florida Society of Otolaryngology (FSO) were surveyed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010six ASPO members (20.4%) and 22 members of FSO (14.6%) responded. When asked about the management of a pediatric patient with acute otitis media and a history of a nonsevere immunoglobulin E (IgE)\u2010mediated amoxicillin allergy, 54% of ASPO respondents indicated they would initiate guideline\u2010recommended cefdinir, whereas only 27% of FSO respondents chose cefdinir (<jats:italic>P<\/jats:italic>\u2009=\u2009.02). Otolaryngologists who are fellowship trained in pediatrics or have pediatric\u2010focused practices were significantly more likely to prescribe cefdinir. Overall, 57% of respondents indicated that they were familiar with the literature regarding the cross\u2010reactivity of \u03b2\u2010lactams, but only 25% of respondents felt that they could easily differentiate a potentially life\u2010threatening IgE\u2010mediated allergy from a non\u2013IgE\u2010mediated drug intolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data show differences between the current recommendations and the behavior of otolaryngologists. Pediatric otolaryngologists were more familiar with the guideline\u2010recommended therapy, likely from their frequent exposure to patients requiring a \u03b2\u2010lactam. Nevertheless, most otolaryngologists could benefit from increased awareness of the current literature. Patients may be receiving less than optimal medication management due to a misidentification of those at risk of life\u2010 threatening allergic cross\u2010reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 125:1822\u20131826, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25227","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T05:43:43Z","timestamp":1425534223000},"page":"1822-1826","source":"Crossref","is-referenced-by-count":3,"title":["Cephalosporin use in penicillin\u2010allergic patients: A survey of otolaryngologists and literature review"],"prefix":"10.1002","volume":"125","author":[{"given":"Michael J.","family":"Persky","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery New York University School of Medicine New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Roof","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery New York University School of Medicine New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University School of Medicine New York New York U.S.A"},{"name":"Department of Environmental Medicine New York University School of Medicine New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Jethanamest","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery New York University School of Medicine New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max M.","family":"April","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery New York University School of Medicine New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-013-8369-8"},{"key":"e_1_2_6_3_1","first-page":"159","article-title":"Nature and extent of penicillin side\u2010reactions, with particular reference to fatalities from anaphylactic shock","volume":"38","author":"Idsoe O","year":"1968","journal-title":"Bull World Health Organ"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/1.suppl_3.107"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60973-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1001\/archinte.1992.00400170105020","article-title":"Results of the National Institute of Allergy and Infectious Diseases Collaborative Clinical Trial to test the predictive value of skin testing with major and minor penicillin derivatives in hospitalized adults","volume":"152","author":"Sogn DD","year":"1992","journal-title":"Arch Inter Med"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.10.007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3488"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.08.002"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25227","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T02:14:11Z","timestamp":1696385651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,5]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/lary.25227"],"URL":"https:\/\/doi.org\/10.1002\/lary.25227","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,5]]}}}