{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:47:01Z","timestamp":1785466021893,"version":"3.56.0"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T00:00:00Z","timestamp":1431129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>Neurofibromatosis types 1 (NF\u20101) and 2 are significant entities to otolaryngologists because they frequently involve head and neck skin, brain, skull base, orbits, and surrounding neural and vascular structures. We present the case of a 52\u2010year\u2010old male with progressive, marked unilateral proptosis due to a multilobulated orbital mass, secondary to biopsy\u2010proven plexiform neurofibroma (PN). Acute worsening of proptosis leading to corneal abrasion, diplopia, and pain required debulking surgery, for which an orbitozygomatic approach was utilized. Genetic testing for NF\u20101 revealed no mutation. This rare case of NF\u2010negative orbital PN and multidisciplinary treatment considerations for expansile orbital tumors are discussed. <jats:italic>Laryngoscope<\/jats:italic>, 125:2457\u20132460, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25232","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T09:49:06Z","timestamp":1431164946000},"page":"2457-2460","source":"Crossref","is-referenced-by-count":4,"title":["Management of an expansile orbital mass: Plexiform neurofibroma decompression by orbitozygomatic approach"],"prefix":"10.1002","volume":"125","author":[{"given":"Kevin J.","family":"Kovatch","sequence":"first","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Purkey","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Martinez\u2010Lage","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital of the University of Pennsylvania Philadelphia Pennsylvania U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta E.","family":"Gausas","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie A.","family":"Loevner","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Sean","family":"Grady","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Bert W.","family":"O'Malley","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"Rassekh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33139"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.5.311"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3182627ea1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/83834938"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1004(200006)15:6<541::AID-HUMU6>3.0.CO;2-N"},{"key":"e_1_2_5_7_1","first-page":"1751","article-title":"Dysplasia of the orbit and adjacent bone associated with plexiform neurofibroma and ocular disease in 42 NF\u20101 patients","volume":"30","author":"Friedrich RE","year":"2010","journal-title":"Anticancer Res"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<2006::AID-CNCR2820571022>3.0.CO;2-6"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.8638"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70414-X"},{"key":"e_1_2_5_11_1","first-page":"175","article-title":"Cranio\u2010orbitozygomatic approach and its orbitopterional modification: microsurgical anatomy and surgical technique","volume":"16","author":"Tarnriover N","year":"2006","journal-title":"Turk Neurosurg"},{"key":"e_1_2_5_12_1","first-page":"43","article-title":"Orbitozygomatic approach to skull base lesions","volume":"10","author":"Deda H","year":"2000","journal-title":"Turk Neurosurg"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25232","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:25:18Z","timestamp":1696605918000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,9]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/lary.25232"],"URL":"https:\/\/doi.org\/10.1002\/lary.25232","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,9]]}}}