{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:42:36Z","timestamp":1790408556986,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T00:00:00Z","timestamp":1427673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The aim of this study was to evaluate the long\u2010term influence of intratympanic gadolinium\u2010based contrast agent on hearing function in patients with possible M\u00e9ni\u00e8re's disease and normal auditory thresholds who were undergoing locally enhanced magnetic resonance imaging scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective observational cohort study in a tertiary referral university hospital ear, nose, and throat department.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2009 and 2012, 17 patients with possible or probable M\u00e9ni\u00e8re's disease and a four\u2010tone pure\u2010tone average baseline of &lt;25 dB were recruited for our study. Before undergoing intratympanic injection of gadolinium\u2010based contrast agent, all patients underwent a complete audiological evaluation. The study population was then invited back after at least 6 months postinjection for a follow\u2010up auditory evaluation. This consisted of comprehensive clinical and audiological tests on both sides and were evaluated according to the ototoxicity guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A long\u2010term evaluation of our study group revealed no significant difference in the air\u2010conduction pure\u2010tone average. Furthermore, no statistical difference at individual frequencies compared to baseline was found. There was no evidence of ototoxicity in the injected ear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term hearing function assessment after intratympanic application of gadolinium\u2010based agent showed no evidence of ototoxicity. The use of intratympanic gadolinium\u2010based agent in the diagnosis of M\u00e9ni\u00e8r\u00e9s disease is currently a helpful tool, and seems to be a safe method, especially with regard to auditory function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 125:2366\u20132370, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25259","type":"journal-article","created":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T23:48:45Z","timestamp":1427759325000},"page":"2366-2370","source":"Crossref","is-referenced-by-count":28,"title":["Hearing function after intratympanic application of gadolinium\u2010based contrast agent: A long\u2010term evaluation"],"prefix":"10.1002","volume":"125","author":[{"given":"Julia","family":"Louza","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Ludwig\u2010Maximilians\u2013University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Ludwig\u2010Maximilians\u2013University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"G\u00fcrkov","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Ludwig\u2010Maximilians\u2013University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31802c300c"},{"key":"e_1_2_7_3_1","first-page":"353","article-title":"Magnetic resonance imaging of the inner ear in M\u00e9ni\u00e8re's disease","volume":"15","author":"Pyykk\u00f6 I","year":"2010","journal-title":"Otolaryngol Clin North Am"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/MAO.0b013e31825d9a95","article-title":"In vivo visualized endolymphatic hydrops and inner ear functions in patients with electrocochleographically confirmed M\u00e9ni\u00e8re's disease","volume":"33","author":"G\u00fcrkov R","year":"2012","journal-title":"Otol Neurotol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7458-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2751-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23725"},{"key":"e_1_2_7_8_1","volume-title":"7. 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