{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:21:27Z","timestamp":1769008887808,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Assess the diagnostic and prognostic relevance of intraglandular lymph node (IGLN) metastases in primary parotid gland carcinomas (PGCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective study at a tertiary referral university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the records of 95 patients with primary PGCs, treated at least surgically, between 1997 and 2010. We assessed the clinicopathological associations of IGLN metastases, their prognostic significance, and predictive value in the diagnosis of occult neck lymph node metastases<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four (25.26%) patients had IGLN metastases. This feature was significantly more prevalent in patients with advanced pT status (<jats:italic>P<\/jats:italic>\u2009=\u2009.01), pN status (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01), and overall stage (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001); high\u2010risk carcinomas (<jats:italic>P<\/jats:italic>\u2009=\u2009.01); as well as in patients with treatment failures (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). IGLN involvement was significantly associated with decreased univariate disease\u2010free survival (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Positive and negative predictive values and accuracy for IGLN involvement in the detection of occult neck lymph node metastases were 63.64%, 90.48%, and 84.91%, respectively. The diagnostic values were generally higher in patients with low\u2010risk subtype of PGCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IGLN involvement provides prognostic information and is associated with advanced tumoral stage and higher risk of recurrence. This feature could be used as a potential readout to determine whether a neck dissection in clinically negative neck lymph nodes is needed or not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 125:2099\u20132106, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25342","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T16:28:04Z","timestamp":1430929684000},"page":"2099-2106","source":"Crossref","is-referenced-by-count":25,"title":["Implications of intraglandular lymph node metastases in primary carcinomas of the parotid gland"],"prefix":"10.1002","volume":"125","author":[{"given":"Llu\u00eds","family":"Nisa","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"},{"name":"Department of Radiation Oncology Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"},{"name":"Department of Clinical Research University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Salmina","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias Stephan","family":"Dettmer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"},{"name":"Institute of Pathology University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; Neck Surgery Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Matthias","family":"Aebersold","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"},{"name":"Department of Clinical Research University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Borner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head &amp; 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