{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:11:04Z","timestamp":1781889064257,"version":"3.54.5"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>A 40\u2010year\u2010old woman was referred by her primary care physician for evaluation after a routine physical exam revealed bilateral brownish pigmentation of the tympanic membrane. Head and neck examination in the otolaryngology clinic revealed bluish hue of both sclera, teeth, and portions of her pinnae. A hearing test revealed bilateral mild sensorineural hearing loss. The patient had a history of taking minocycline for 14 years, and the hyperpigmentation that she had is known to be a rare complication of prolonged minocycline use. However, to our knowledge, this is the first case showing photographic evidence of minocycline\u2010induced tympanic membrane hyperpigmentation. Minocycline\u2010induced hyperpigmentation should be considered when a patient presents with brown or blue discoloration of the tympanic membrane. <jats:italic>Laryngoscope<\/jats:italic>, 125:2601\u20132603, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25365","type":"journal-article","created":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T15:48:47Z","timestamp":1433864927000},"page":"2601-2603","source":"Crossref","is-referenced-by-count":10,"title":["Minocycline\u2010induced hyperpigmentation of tympanic membrane, sclera, teeth, and pinna"],"prefix":"10.1002","volume":"125","author":[{"given":"Stephen","family":"Reese","sequence":"first","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Grundfast","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Boston Medical Center Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,8]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/archderm.1985.01660050070017","article-title":"Hyperpigmentation of the skin associated with minocycline therapy","volume":"121","author":"Gordon G","year":"1985","journal-title":"Arch Dermatol"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00369.x"},{"key":"e_1_2_4_4_1","volume-title":"GeneReviews\u00ae","author":"Introne WJ","year":"2003"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199818060-00004"},{"key":"e_1_2_4_6_1","first-page":"457","article-title":"Minocycline hyperpigmentation: skin, tooth, nail, and bone involvement","volume":"33","author":"Wolfe ID","year":"1984","journal-title":"Cutis"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20606"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01421.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1980.03310100021021"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.103036"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1008348"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215111001903"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25365","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:25:25Z","timestamp":1696605925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,8]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/lary.25365"],"URL":"https:\/\/doi.org\/10.1002\/lary.25365","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,8]]}}}