{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:52:56Z","timestamp":1792144376840,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Postthyroidectomy voice changes are common even without apparent laryngeal nerve injury. Our study evaluated the impact of open cervical thyroidectomy on five acoustic voice parameters in the early (&lt; 3 months) and late (\u2265 3 months) postoperative periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was performed to identify studies that quantitatively assessed voice quality by acoustic voice analysis before and after thyroidectomy. Parameters included average fundamental frequency (F<jats:sub>0<\/jats:sub>, Hz), jitter (%), shimmer (%), noise\u2010to\u2010harmonic ratio (NHR), and maximum phonation time (MPT) (in secs). Meta\u2010analysis was performed using both fixed\u2010 and random\u2010effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 896 patients were analyzed. Relative to baseline, F<jats:sub>0<\/jats:sub> significantly worsened in the early period (from 194.9\u2009\u00b1\u200934.9 Hz to 188.0\u2009\u00b1\u200934.0 Hz, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). This was equivalent to a quarter\u2010tone loss (<jats:italic>P<\/jats:italic>\u2009=\u20090.004). Shimmer (from 3.15\u2009\u00b1\u20091.59% to 3.19\u2009\u00b1\u20091.70%, <jats:italic>P<\/jats:italic>\u2009=\u20090.040) and MPT (from 17.9 secs to 16.7 secs, <jats:italic>P<\/jats:italic>\u2009=\u20090.046) also worsened in the early period, whereas jitter and NHR remained unchanged in the early and late periods. Males suffered greater deterioration in F<jats:sub>0<\/jats:sub> (from 120.6\u2009\u00b1\u200918.8 Hz to 111.0\u2009\u00b1\u200918.5 Hz, <jats:italic>P<\/jats:italic>\u2009=\u20090.048) and in NHR (from 0.12\u2009\u00b1\u20090.02 to 0.16\u2009\u00b1\u20090.03, <jats:italic>P<\/jats:italic>\u2009=\u20090.019) than females in the early period. Four of the five acoustic parameters (F<jats:sub>0<\/jats:sub>, jitter, shimmer, and NHR) significantly worsened after total thyroidectomy (TT) and not after lesser resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>F<jats:sub>0<\/jats:sub>, shimmer, and MPT significantly worsened in the early and not in the late postoperative period. F<jats:sub>0<\/jats:sub> impairment was perceptually significant. Males and those undergoing TT suffered greater voice impairment than their counterparts during the early period. <jats:italic>Laryngoscope<\/jats:italic>, 126:528\u2013537, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25452","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T18:25:57Z","timestamp":1436293557000},"page":"528-537","source":"Crossref","is-referenced-by-count":54,"title":["A systematic review and meta\u2010analysis on acoustic voice parameters after uncomplicated thyroidectomy"],"prefix":"10.1002","volume":"126","author":[{"given":"Brian H. H.","family":"Lang","sequence":"first","affiliation":[{"name":"Department of Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos K. H.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Primary Care 3\/F Ap Lei Chau Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estella P. 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