{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:22:45Z","timestamp":1761744165390},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Chronic laryngitis (CL) is common and costly. One of the most common causes of CL is thought to be laryngopharyngeal reflux, although a significant percentage of individuals fail to get better with acid suppressive therapy. The role of other potential causes of CL such as allergy and environmental pollution has not been thoroughly investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the association between iron soot, house dust mite allergen (HDMA), and CL in an established animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four guinea pigs were separated into four 6\u2010week exposure groups: 1) saline (allergen control)\u2009+\u2009filtered air (pollution control); 2) HDMA (<jats:italic>Dermatophygoides farinae<\/jats:italic>)\u2009+\u2009filtered air; 3) saline\u2009+\u2009combustion particulates; or 4) HDMA\u2009+\u2009combustion particulates. The primary outcome measure was mean eosinophil profile (MEP) in glottic, subglottic, and trachea epithelium and submucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The combination of iron soot and HDMA caused eosinophilia (elevated MEP) in the glottic (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.06), subglottic (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and trachea (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) submucosa and epithelium (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of HDMA and iron soot resulted in laryngeal eosinophilia in an established guinea pig model of CL. The data support the notion that factors other than reflux may cause CL. Further investigation into eosinophilic laryngitis as a distinct clinical entity caused by exposure to environmental allergen and pollution is warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>N\/A. <jats:italic>Laryngoscope<\/jats:italic>, 126:108\u2013112, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25467","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T12:59:36Z","timestamp":1437483576000},"page":"108-112","source":"Crossref","is-referenced-by-count":17,"title":["Soot and house dust mite allergen cause eosinophilic laryngitis in an animal model"],"prefix":"10.1002","volume":"126","author":[{"given":"Peter C.","family":"Belafsky","sequence":"first","affiliation":[{"name":"Department of Otolaryngology UC Davis Health System Sacramento"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Peake","sequence":"additional","affiliation":[{"name":"Center for Health and the Environment, University of California Davis Davis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzette M.","family":"Smiley\u2010Jewell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology UC Davis Health System Sacramento"},{"name":"Center for Health and the Environment, University of California Davis Davis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil P.","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of California Irvine Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Dworkin\u2010Valenti","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Detroit Medical Center Detroit Michigan U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent E.","family":"Pinkerton","sequence":"additional","affiliation":[{"name":"Center for Health and the Environment, University of California Davis Davis"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.12.1534"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.125760"},{"key":"e_1_2_6_5_1","first-page":"10","article-title":"Symptoms and findings of laryngopharyngeal reflux","volume":"81","author":"Belafsky PC","year":"2002","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","unstructured":"PearsonJP ParikhS OrlandoRC et al. 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