{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:19:52Z","timestamp":1771467592303,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Center for Complementary and Alternative Medicine, National Institutes of Health","award":["#R21 AT003879-01"],"award-info":[{"award-number":["#R21 AT003879-01"]}]},{"name":"Hong Kong Research Grant Council","award":["HKU782509-2009"],"award-info":[{"award-number":["HKU782509-2009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Acupuncture is a less\u2010invasive procedure when compared with surgical treatment for benign vocal pathologies caused by vocal overuse. This study aimed to determine the wound\u2010healing effect of acupuncture in treating phonotraumatic vocal fold lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Two\u2010way, mixed\u2010model, between\u2010 and within\u2010subjects, prospective randomized, placebo\u2010controlled, blinded group design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen dysphonic individuals with vocal nodules were recruited from a university clinic in Hong Kong. Each participant was randomly assigned to receive one session of either genuine or sham acupuncture. The genuine acupuncture group (n\u2009=\u20099) received needles puncturing nine voice\u2010related acupoints for 30 minutes, whereas the sham acupuncture group (n\u2009=\u20098) received blunted needles stimulating the skin surface of the nine acupoints for the same frequency and duration. Laryngeal secretions were suctioned from the surface of the vocal folds immediately before, immediately after, and 24 hours after the acupuncture. The protein concentration levels of wound\u2010healing\u2013related cytokines (interleukin [IL]\u20101\u03b2 and IL\u201010) in these secretion samples were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following acupuncture, a significant increase in the anti\u2010inflammatory cytokine IL\u201010 was found in the genuine acupuncture group (n\u2009=\u20099) but not in the sham acupuncture group (n\u2009=\u20098).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings showed that acupuncture of voice\u2010related acupoints facilitated an anti\u2010inflammatory process in phonotraumatic vocal pathologies. This could be considered as supporting evidence to consider acupuncture as a less\u2010invasive alternative option, when compared to surgery, for treating phonotraumatic vocal pathologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1b <jats:italic>Laryngoscope<\/jats:italic>, 126:E18\u2013E22, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25483","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T14:17:30Z","timestamp":1438265850000},"source":"Crossref","is-referenced-by-count":9,"title":["Wound\u2010healing effect of acupuncture for treating phonotraumatic vocal pathologies: A cytokine study"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3135-2618","authenticated-orcid":false,"given":"Edwin M. L.","family":"Yiu","sequence":"first","affiliation":[{"name":"Division of Speech &amp; Hearing Sciences University of Hong Kong Pokfulam Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M. K.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Speech &amp; Hearing Sciences University of Hong Kong Pokfulam Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole Y. K.","family":"Li","sequence":"additional","affiliation":[{"name":"School of Communication Sciences and Disorders, McGill University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hong Kong, Queen Mary Hospital Pokfulam Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine Verdolini","family":"Abbott","sequence":"additional","affiliation":[{"name":"Communication Science and Disorders University of Pittsburgh Pittsburgh Pennsylvania U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Kwong","sequence":"additional","affiliation":[{"name":"Division of Speech &amp; Hearing Sciences University of Hong Kong Pokfulam Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estella P. 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