{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:41:47Z","timestamp":1791830507692,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T00:00:00Z","timestamp":1438992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To determine the effect of cochlear implantation on tinnitus perception in patients with severe bilateral postlingual sensorineural hearing loss and to demonstrate possible differences between unilateral and bilateral cochlear implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight adult patients were included in this prospective study, as part of a multicenter randomized controlled trial investigating the benefits of bilateral cochlear implantation versus unilateral cochlear implantation. Pre\u2010 and postoperative tinnitus perception scores were evaluated, before and 1 year after implantation on three tinnitus questionnaires; the Tinnitus Handicap Inventory (THI), the Tinnitus Questionnaire (TQ), and a visual analogue scale for tinnitus burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before implantation, the tinnitus prevalence was 42.1% (16 of 38) in the whole study group. One year after implantation, the tinnitus questionnaire scores had decreased in 71.4% according to the TQ and 80.0% according to the THI. Tinnitus was induced after cochlear implantation in six patients, five in the bilateral and one in the unilateral group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study shows that cochlear implantation is effective in the reduction of tinnitus in patients with bilateral sensorineural hearing loss who suffered from preoperative tinnitus. Conversely, tinnitus may also increase or even be induced by the cochlear implantation itself. Cochlear implant candidates should be well informed about these possible consequences before undergoing surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b <jats:italic>Laryngoscope<\/jats:italic>, 126:956\u2013961, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25493","type":"journal-article","created":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T13:35:39Z","timestamp":1439040939000},"page":"956-961","source":"Crossref","is-referenced-by-count":35,"title":["Effect of unilateral and simultaneous bilateral cochlear implantation on tinnitus: A Prospective Study"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-1313","authenticated-orcid":false,"given":"Alice","family":"van Zon","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette E.","family":"Smulders","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geerte G. J.","family":"Ramakers","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Stegeman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana L.","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijsbert A.","family":"Van Zanten","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Brain Center Rudolf Magnus, University Medical Center Utrecht Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Stokroos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Maastricht University Medical Center Maastricht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Hendrice","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Maastricht University Medical Center Maastricht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolien H.","family":"Free","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Graduate School of Medical Sciences, Research School of Behavioral and Cognitive Neurosciences, University Medical Center Groningen  Groningen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Maat","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Graduate School of Medical Sciences, Research School of Behavioral and Cognitive Neurosciences, University Medical Center Groningen  Groningen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan H. 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