{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:18:44Z","timestamp":1790011124550,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The purpose of this study was to retrospectively review patients with human papillomavirus (HPV)\u2013associated oropharyngeal squamous cell carcinoma (OPSCC) for the presence of retropharyngeal lymph nodes (RPLNs) prior to treatment using positron emission tomography\/computed tomography (PET\/CT), and to determine if the presence of RPLNs is of utility in predicting outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective review of patient data from a single institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred thirty patients with a diagnosis of HPV\u2010associated OPSCC were identified from 2002 to 2013. The presence of RPLNs was determined primarily from findings on PET\/CT as reviewed in a standardized fashion by two neuroradiologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 230 patients, 165 had pretreatment PET\/CT imaging available for review. There were a total of 16 patients (9.70%) with evidence of RPLNs. Among patients positive for RPLNs pretreatment, with an average follow\u2010up of 2 years, there was a 5.2\u2010times greater odds of having recurrence or death (31.3% vs. 8.1%, <jats:italic>P<\/jats:italic>\u2009=\u2009.004). When T and N stage were adjusted for with multiple regression, there was no significant association between RPLN status and recurrence free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is a unique investigation utilizing PET\/CT to classify RPLN status in HPV\u2010associated OPSCC. RPLNs were relatively common in our HPV\u2010associated OPSCC cohort at 9.70%, at the low end of the quoted positivity of 10% to 27% in all OPSCC. A combination of PET\/CT is useful in identifying RPLNs. Prospective investigation will be needed to determine the sensitivity and specificity of PET\/CT in identifying RPLNs, and the precise impact of RPLNs on HPV\u2010associated OPSCC treatment and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 125:2503\u20132508, 2015<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25495","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T14:18:24Z","timestamp":1438265904000},"page":"2503-2508","source":"Crossref","is-referenced-by-count":25,"title":["Retropharyngeal lymph node involvement in human papillomavirus\u2013associated oropharyngeal squamous cell carcinoma"],"prefix":"10.1002","volume":"125","author":[{"given":"Michael","family":"Baxter","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Naval Medical Center San Diego San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason Y. K.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins Medical Institutions Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech K.","family":"Mydlarz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins Medical Institutions Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore V.","family":"Labruzzo","sequence":"additional","affiliation":[{"name":"Department of Radiology\u2013Neuroradiology Johns Hopkins Medical Institutions Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Kiess","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Johns Hopkins Medical Institutions Baltimore Maryland U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick K.","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins Medical Institutions Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aygun","family":"Nafi","sequence":"additional","affiliation":[{"name":"Department of Radiology\u2013Neuroradiology Johns Hopkins Medical Institutions Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agrawal","family":"Nishant","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins Medical Institutions Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-23499-6_777"},{"key":"e_1_2_6_3_1","volume-title":"CURRENT Diagnosis & Treatment in Otolaryngology\u2014Head & Neck Surgery","author":"Lee N","year":"2012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2013.09.006"},{"key":"e_1_2_6_5_1","first-page":"258","article-title":"Human papillomavirus\u2013associated cancers\u2014United States, 2004\u20132008","volume":"61","author":"Centers for Disease Control and Prevention","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/crad.2000.0510"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.02.027"},{"key":"e_1_2_6_8_1","first-page":"709","article-title":"Computed tomography of cervical and retropharyngeal lymph nodes: normal anatomy, variants of normal, and applications in staging head and neck cancer","volume":"148","author":"Mancuso AA","year":"1983","journal-title":"Part I: normal anatomy. Radiology"},{"key":"e_1_2_6_9_1","first-page":"715","article-title":"Computed tomography of cervical and retropharyngeal lymph nodes: normal anatomy, variants of normal, and applications in staging head and neck cancer","volume":"148","author":"Mancuso AA","year":"1983","journal-title":"Part II: pathology. Radiology"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21526"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500504259"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28195"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.02.034"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880170304"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.08.008"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3283360133"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23292"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20593"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.101.5_573"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-05726-2"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25495","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:24:54Z","timestamp":1696605894000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,30]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/lary.25495"],"URL":"https:\/\/doi.org\/10.1002\/lary.25495","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,30]]}}}