{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:08:58Z","timestamp":1787170138603,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>Mandibular advancement devices are an alternative to continuous positive airway pressure for patients with mild or moderate obstructive sleep apnea\/hypopnea syndrome (OSAHS). The main aim of this review was to assess the effectiveness of different devices in treating OSAHS, based on polysomnographic measurements such as the apnea\/hypopnea index (AHI) and oxygen saturation, and on changes in the upper airway and improvements in the most common symptoms: snoring and somnolence. Their adverse effects were also noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following an exhaustive search in the Medline, Scopus, and Cochrane Library databases, 22 articles published in the past 10 years met the quality and inclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using mandibular advancement devices during the hours of sleep helps to prevent snoring and excessive daytime sleepiness, reduce the AHI significantly, and bring about beneficial changes in the upper airway. Adjustable and custom\u2010made mandibular advancement devices give better results than fixed and prefabricated appliances. Monobloc devices give rise to more adverse events, although these are generally mild and transient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mandibular advancement devices increase the area of the airway. They bring the soft palate, tongue, and hyoid bone forward and activate the masseter and submental muscles, preventing closure. All these effects reduce the AHI, increase the oxygen saturation, and improve the main symptoms of OSAHS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      NA\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 126:507\u2013514, 2016\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.25505","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T09:48:57Z","timestamp":1438249737000},"page":"507-514","source":"Crossref","is-referenced-by-count":89,"title":["Effectiveness of mandibular advancement appliances in treating obstructive sleep apnea syndrome: A systematic review"],"prefix":"10.1002","volume":"126","author":[{"given":"Sara","family":"Serra\u2010Torres","sequence":"first","affiliation":[{"name":"Stomatology Department Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4363-2713","authenticated-orcid":false,"given":"Carlos","family":"Bellot\u2010Arc\u00eds","sequence":"additional","affiliation":[{"name":"Stomatology Department Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Montiel\u2010Company","sequence":"additional","affiliation":[{"name":"Stomatology Department Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Marco\u2010Algarra","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit University Clinical Hospital, Faculty of Medicine and Dentistry, University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Almerich\u2010Silla","sequence":"additional","affiliation":[{"name":"Stomatology Department Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,30]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"International Classification of Sleep Disorders: Diagnostic and Coding Manual","author":"American Academy of Sleep Medicine","year":"2005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00094304"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjh067"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjq079"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5664\/jcsm.1910","article-title":"A combination appliance for obstructive sleep apnea: the effectiveness of mandibular advancement and tongue retention","volume":"8","author":"Dort L","year":"2012","journal-title":"J Clin Sleep Med"},{"key":"e_1_2_6_7_1","volume-title":"Sleep Apnea and Snoring: Medical and Surgical Treatment","author":"Friedman M","year":"2009"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00169.2005"},{"key":"e_1_2_6_9_1","first-page":"w13276","article-title":"Mandibular advancement splints for the treatment of sleep apnoea syndrome","volume":"141","author":"Sutherland K","year":"2011","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00148208"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-009-0298-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91522-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.4.362"},{"key":"e_1_2_6_14_1","first-page":"1561","article-title":"Accidents in obstructive sleep apnea patients treated with nasal continuous positive airway pressure","volume":"112","author":"Krieger J","year":"1997","journal-title":"A prospective study. Chest"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.2.9803121"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.2.9804061"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.3.707"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9903079"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-003-0119-3"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.6.1477"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200203-208OC"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-003-0131-7"},{"issue":"1","key":"e_1_2_6_23_1","first-page":"CD004435","article-title":"Oral appliances for obstructive sleep apnoea","author":"Lim J","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.5664\/JCSM.1300"},{"key":"e_1_2_6_25_1","first-page":"385","article-title":"OSAS treatment with oral appliance: assessment of our experience through the use of a new device","volume":"17","author":"Gasparini G","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-18"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5664\/jcsm.3460","article-title":"Oral appliance treatment for obstructive sleep apnea: an update","volume":"15","author":"Sutherland K","year":"2014","journal-title":"J Clin Sleep Med"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2011.06.020"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-0965"},{"key":"e_1_2_6_30_1","first-page":"336","article-title":"The impact of the Adjustable PM Positioner appliance in the treatment of obstructive sleep apnoea","volume":"3","author":"Giannasi LC","year":"2008","journal-title":"Arch Med Sci"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.11607\/ijp.3284"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1590\/S2176-94512012000200017"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24607"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.26365"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200701-114OC"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-012-0721-3"},{"key":"e_1_2_6_37_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.47102\/annals-acadmedsg.V37N8p637","article-title":"Airway and craniofacial changes with mandibular advancement device in Chinese with obstructive sleep apnoea","volume":"37","author":"Poon KH","year":"2008","journal-title":"Acad Med Singapore"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00077409"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2009.00738.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12006"},{"key":"e_1_2_6_41_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.5665\/sleep.2458","article-title":"Tongue and lateral upper airway movement with mandibular advancement","volume":"3","author":"Brown EC","year":"2013","journal-title":"Sleep"},{"key":"e_1_2_6_42_1","first-page":"586","article-title":"The effect of a mandibular advancement splint on electromyographic activity of the submental and masseter muscles in patients with obstructive sleep apnea","volume":"22","author":"Kurtulmus H","year":"2009","journal-title":"Int J Prosthodont"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2007.00615.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.2319\/030309-122.1"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0737-x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1179\/146531204225020589"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1590\/S2176-94512013000300019"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25505","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T02:45:59Z","timestamp":1695696359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,30]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1002\/lary.25505"],"URL":"https:\/\/doi.org\/10.1002\/lary.25505","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,30]]}}}