{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:13:52Z","timestamp":1773015232890,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To provide the final results from the REMODEL (randomized evaluation of maxillary antrostomy versus ostial dilation efficacy through long\u2010term follow\u2010up) full\u2010study cohorts and perform meta\u2010analyses of standalone balloon sinus dilation studies to explore long\u2010term outcomes in a large patient sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Randomized controlled trial and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Final outcomes from the REMODEL randomized trial, including a larger cohort of 135 patients treated with functional endoscopic sinus surgery (FESS) or in\u2010office balloon dilation, were evaluated. One hundred thirty patients had 12\u2010month data, 66 had 18\u2010month data, and 25 had 24\u2010month data. In addition, a meta\u2010analysis evaluated outcomes from six studies including 358 standalone balloon dilation patients with up to 24 months follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Outcomes out to 2 years from the REMODEL full\u2010study cohort are consistent with 6\u2010month and 12\u2010month outcomes. In the meta\u2010analysis of standalone balloon dilation studies, technical success is 97.5%, and mean 20\u2010item Sino\u2010Nasal Outcomes Test scores are significantly and clinically improved at all time points (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). There are significant reductions (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) in work\/school days missed, homebound days, physician\/nurse visits, acute infections, and antibiotic prescriptions. Mean recovery time is 1.4 days. Comparison of 12\u2010month symptom improvements and revision rates between the REMODEL FESS arm (n\u2009=\u200959), REMODEL balloon dilation arm (n\u2009=\u200971), and pooled single\u2010arm standalone balloon dilation studies (n\u2009=\u2009243) demonstrated no statistical difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All outcomes are comparable between FESS and balloon dilation at all time points from 6 months to 24 months. Balloon dilation produces faster recovery, less postoperative pain, and fewer debridements than FESS. There is significant, durable benefit in a large series of 358 patients undergoing standalone balloon dilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1b. <jats:italic>Laryngoscope<\/jats:italic>, 126:44\u201350, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25507","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T14:23:25Z","timestamp":1438266205000},"page":"44-50","source":"Crossref","is-referenced-by-count":51,"title":["<scp>REMODEL<\/scp> larger cohort with long\u2010term outcomes and meta\u2010analysis of standalone balloon dilation studies"],"prefix":"10.1002","volume":"126","author":[{"given":"Rakesh K.","family":"Chandra","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Vanderbilt University School of Medicine Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey L.","family":"Cutler","sequence":"additional","affiliation":[{"name":"Associates of Otolaryngology Denver Colorado U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin C.","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Northwestern University Feinberg School of Medicine Chicago Illinois"},{"name":"Associates of Otolaryngology Denver Colorado U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul T.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Vanderbilt University School of Medicine Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3970"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4064"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4043"},{"key":"e_1_2_7_5_1","unstructured":"2012 Vendome Healthcare Media New York NY JD Gould In\u2010office balloon dilation: procedure techniques and outcomes using a malleable multi\u2010sinus dilation tool. 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