{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:46:11Z","timestamp":1789832771279,"version":"4.0.1"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Supraglottic injection of botulinum toxin (Botox) has been described as an effective treatment for adductor spasmodic dysphonia (ADSD). Anecdotal evidence suggests that the patients have little to no breathiness after injection, but no formal longitudinal studies have been carried out to date. The purpose of this study was to examine the voice outcomes in patients with ADSD after supraglottic Botox injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with ADSD who were treated with supraglottic Botox injections completed a qualitative self\u2010evaluation of voice function after injection using the percentage of normal function (PNF) scale, a validated, quantitative scale from 0% (no function) to 100% (normal function). Posttreatment voice improvement after injection was determined using a Voice Handicap Index\u201010 (VHI\u201010) questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 198 supraglottic injections were performed between July 2011 and October 2014. Twenty\u2010five questionnaires were completed. Mean postinjection PNF was 95.0% \u00b1 8.4% and was significantly increased from the preinjection mean PNF (62.5%) \u00b1 22.6% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The mean best VHI\u201010 for all injections was 7.23. In 19 of 25 patients (76%), there was no reduction in PNF in the early postinjection period. In the remaining six patients (24%), the decline in mean vocal function was 9.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Supraglottic Botox injection is an effective treatment for ADSD. Postinjection voice is significantly improved, and the majority of patients do not experience breathy voice\/decline in vocal function after injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 126:118\u2013121, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25515","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T11:36:35Z","timestamp":1444908995000},"page":"118-121","source":"Crossref","is-referenced-by-count":31,"title":["Botulinum toxin treatment of false vocal folds in adductor spasmodic dysphonia: Functional outcomes"],"prefix":"10.1002","volume":"126","author":[{"given":"C. Blake","family":"Simpson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Texas Health Sciences Center at San Antonio San Antonio Texas U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Texas Health Sciences Center at San Antonio San Antonio Texas U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne L.","family":"Hatcher","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Emory University Atlanta Georgia U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Michalek","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of Texas Health Sciences Center at San Antonio San Antonio Texas U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000145959.50513.5e"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815e8be0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24292"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21395"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200409000-00009"},{"key":"e_1_2_6_7_1","volume-title":"Operative Techniques in Laryngology","author":"Rosen CA","year":"2008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199707000-00022"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12333"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318124a97b"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25515","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T22:35:43Z","timestamp":1696545343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,15]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/lary.25515"],"URL":"https:\/\/doi.org\/10.1002\/lary.25515","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,15]]}}}