{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:42:17Z","timestamp":1778740937563,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T00:00:00Z","timestamp":1440547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["NIDCD U24 DC011968-01"],"award-info":[{"award-number":["NIDCD U24 DC011968-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To determine if peripheral vestibular otopathology is present in human temporal bones with otosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Comparative human temporal bone study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010four human temporal bones from 46 subjects with otosclerosis (mean age of 61\u2009\u00b1\u200918 years) and 20 within histologically normal limits from 17 subjects (mean age of 59\u2009\u00b1\u200914 years) were included in this study. Temporal bones with otosclerosis were divided into those with and without endosteal involvement. Using differential interference contrast microscopy at 1008\u00d7 magnification, type I and type II vestibular hair cell counts were performed on each vestibular sense organ in which the neuroepithelia was oriented perpendicular to the plane of section. The organ\u2010specific cell densities (cells\/0.01 mm<jats:sup>2<\/jats:sup> surface area) were compared between the groups with and without endosteal involvement, and also compared to counts in the nonotosclerosis control group using Student's <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean type I and type II hair cell densities of all vestibular structures in the group with endosteal involvement were significantly lower compared to the group without endosteal involvement. Mean type I and type II hair cell densities of all vestibular structures in the group with endosteal involvement were also significantly lower compared to the control group, but they were not in the group without endosteal involvement compared to the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Endosteal involvement of otosclerotic foci is associated with vestibular hair cell loss that may contribute to the vestibular symptoms in otosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>N\/A. <jats:italic>Laryngoscope<\/jats:italic>, 126:E118\u2013E122, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25523","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T17:16:02Z","timestamp":1440609362000},"source":"Crossref","is-referenced-by-count":13,"title":["Quantitative assessment of vestibular otopathology in otosclerosis: A temporal bone study"],"prefix":"10.1002","volume":"126","author":[{"given":"\u00d6mer","family":"H\u0131zl\u0131","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota"},{"name":"Giresun A. Ilhan Ozdemir State Hospital Giresun"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota"},{"name":"Gebze Fatih State Hospital Gebze Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Schachern","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeyoun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Paparella","sequence":"additional","affiliation":[{"name":"Paparella Ear Head and Neck Institute Minneapolis Minnesota U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebahattin","family":"Cureoglu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,26]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Diseases of the Ear","author":"Toynbee J","year":"1860"},{"key":"e_1_2_6_3_1","first-page":"309","article-title":"Uber primare erkrankung der knochernen labyrinth\u2010kapsel","volume":"25","author":"Politzer A","year":"1893","journal-title":"Zeitschr Ohrenheil"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164801300043361"},{"key":"e_1_2_6_5_1","volume-title":"Cummings Otolaryngology Head & Neck Surgery","author":"Flint PW","year":"2010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110500308"},{"key":"e_1_2_6_7_1","first-page":"111","article-title":"Saccular function in otosclerosis patients: bone conducted\u2010vestibular evoked myogenic potential analysis","volume":"52","author":"Amali A","year":"2014","journal-title":"Acta Med Iran"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1201\/b15118"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100065579"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989010300116"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199910000-00004"},{"key":"e_1_2_6_12_1","first-page":"1","article-title":"Studies on the structure and innervation of the sensory epithelium of the cristae ampulares in the guinea pig; a light and electron microscopic investigation","volume":"126","author":"Wersall J","year":"1956","journal-title":"Acta Otolaryngol Suppl"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894001090S505"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/00034894001090S504","article-title":"Temporal bone studies of the human peripheral vestibular system. 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