{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:20:28Z","timestamp":1769595628359,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,22]],"date-time":"2015-08-22T00:00:00Z","timestamp":1440201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Squamous cell carcinoma of the nasal cavity (NCSCC) is an infrequent malignancy that has been historically difficult to characterize. This study provides new insight into NCSCC utilizing a population\u2010based database. We analyze the propensity for cervical and distant metastasis from NCSCC, as well as survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective database analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Surveillance, Epidemiology, and End Results (SEER) database (2004\u20132012) was queried for NCSCC cases. Data were analyzed with respect to various demographic and clinicopathologic factors. The results were further examined for regional and distant metastasis. Survival was analyzed using the Kaplan\u2010Meier model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,180 cases of NCSCC were identified in the SEER database between 2004 and 2012. The mean age at diagnosis was 65.8 years. American Joint Committee on Cancer stage was known in 1,050 cases, of which 53.4% were stage I, 13.3% were stage II, 10.2% were stage III, and 23.0% were stage IV. By tumor (T) stage classification, T1 was the most common (56.6%), followed by T4 (19.3%). Most cases had no nodal (N) involvement at diagnosis (90.8%). Cervical nodal involvement was present in 9.1% of cases, while distant metastasis was seen in 1.9%. Five\u2010year disease\u2010specific survival was 69.5% overall, 39.6% in cases with neck involvement and 0.0% for metastatic cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study represents the only known population\u2010based investigation of NCSCC. Metastasis to cervical nodes or distant sites, especially with T1 tumors, is rare. However, any cervical involvement or distant metastasis discovered on presentation is a poor prognostic indicator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 126:560\u2013565, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25531","type":"journal-article","created":{"date-parts":[[2015,8,22]],"date-time":"2015-08-22T15:09:26Z","timestamp":1440256166000},"page":"560-565","source":"Crossref","is-referenced-by-count":40,"title":["Squamous cell carcinoma of the nasal cavity: A population\u2010based analysis"],"prefix":"10.1002","volume":"126","author":[{"given":"Aykut A.","family":"Unsal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Facial Plastic Surgery Rowan University School of Osteopathic Medicine Stratford New Jersey U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pariket M.","family":"Dubal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapan D.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey, Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey, Rutgers New Jersey Medical School Newark New Jersey U.S.A"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey, Rutgers New Jersey Medical School Newark New Jersey U.S.A"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School Newark New Jersey U.S.A"},{"name":"Department of Ophthalmology and Visual Science Rutgers New Jersey Medical School Newark New Jersey U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.8.796"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24264"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10143"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.107450"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.9.1079"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2005.04.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21830"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-2171(99)90016-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815581613"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21418"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90194-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(92)90375-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.09.023"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24618"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25111"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21342"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.09.003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21243"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24231"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25266"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21422"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2014.03.003"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24085"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21332"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23543"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25531","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T10:18:05Z","timestamp":1695723485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,22]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/lary.25531"],"URL":"https:\/\/doi.org\/10.1002\/lary.25531","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,22]]}}}