{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:04:17Z","timestamp":1792098257484,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:00:00Z","timestamp":1439337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning","award":["2013R1A1A1012542"],"award-info":[{"award-number":["2013R1A1A1012542"]}]},{"name":"Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (MEST)","award":["2012K1A4A3053142"],"award-info":[{"award-number":["2012K1A4A3053142"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The whole\u2010blood interferon (IFN)\u2010\u03b3 release assay (IGRA) has been studied mainly for diagnosing latent tuberculosis (TB). We prospectively evaluated its diagnostic usefulness in patients with suspected cervical TB lymphadenitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An IGRA was performed in subjects with suspected TB lymphadenitis. To evaluate the diagnostic performance of the IGRA, we calculated the sensitivity and specificity of culture, radiologic imaging, polymerase chain reaction testing, fine needle aspiration, and excisional biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Of the 271 adult patients with suspected TB lymphadenitis, 42 were diagnosed with the disease. The overall sensitivity and specificity of the IGRA were 78.8% and 95.5%, respectively. When the cutoff value of IFN\u2010\u03b3 was set to 0.26 IU\/mL, it met the inclusion criteria for suspicious TB lymphadenitis, with sensitivity and specificity of 83.3% and 95.1%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The IGRA is useful in diagnosing TB lymphadenitis, with high sensitivity and specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 126:378\u2013384, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25540","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T15:13:30Z","timestamp":1439392410000},"page":"378-384","source":"Crossref","is-referenced-by-count":9,"title":["The efficacy of the interferon\u2010\u03b3 release assay for diagnosing cervical tuberculous lymphadenitis: A prospective controlled study"],"prefix":"10.1002","volume":"126","author":[{"given":"Kyung Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Gyeongsang National University Jinju Korea"},{"name":"College of Nursing, Gyeongsang National University Jinju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rock Bum","family":"Kim","sequence":"additional","affiliation":[{"name":"Regional Cardiocerebrovascular Center, Dong\u2010A University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hoon","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Gyeongsang National University Jinju Korea"},{"name":"Institute of Health Sciences, Gyeongsang National University Jinju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800590506"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215001905544"},{"key":"e_1_2_6_4_1","first-page":"S221","article-title":"This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. 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