{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:47:54Z","timestamp":1788544074629,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T00:00:00Z","timestamp":1440806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["973 Project (No. 2011CB504504)"],"award-info":[{"award-number":["973 Project (No. 2011CB504504)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81070785"],"award-info":[{"award-number":["81070785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81170909"],"award-info":[{"award-number":["81170909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective\/Hypothesis<\/jats:title><jats:p>This study aimed at investigating the correlation between a battery of diagnostic symptoms of definite Meniere's disease (MD) and the degree of endolymphatic hydrops (EH) in the inner ear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010four patients diagnosed with unilateral definite MD were enrolled in the study. The hearing levels of all patients at the low, middle, and high frequencies were evaluated. Three\u2010dimensional fluid\u2010attenuated inversion recovery (3D\u2010FLAIR) and three\u2010dimensional real inversion recovery (3D\u2010real IR) magnetic resonance imaging (MRI) were performed 24 hours after bilateral intratympanic injection of gadolinium to assess the presence and grading of EH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Various degrees of EH were observed in the vestibule and\/or each turn of the cochlea in the affected ears of all patients. The duration of MD disease and low\u2010tone and middle\u2010tone hearing thresholds were proportional to the extent of EH in the vestibule and cochlear. However, no significant correlation was demonstrated between EH and other aspects of symptoms such as high\u2010tone hearing loss, tinnitus, and aural fullness. Of all subjects, 16.7% exhibited bilateral EH on MRI exam who were diagnosed with unilateral MD based on diagnostic criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EH in the inner ear of MD patients exhibits a progressive deteriorative trend over time. Low\u2010tone and middle\u2010tone hearing thresholds can indirectly reflect the severity of EH in the cochlea. EH may not be the primary cause of tinnitus and aural fullness in patients with MD. Patients diagnosed with unilateral MD should maintain long\u2010term regular follow\u2010ups for the possibility of developing bilateral EH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 126:974\u2013979, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25576","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T14:15:53Z","timestamp":1441203353000},"page":"974-979","source":"Crossref","is-referenced-by-count":108,"title":["The correlation between symptoms of definite <scp>M<\/scp>eniere's disease and endolymphatic hydrops visualized by magnetic resonance imaging"],"prefix":"10.1002","volume":"126","author":[{"given":"Qianru","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Otology and Skull Base Surgery Hearing Research Key Lab of Health Ministry of China, Eye, Ear, Nose and Throat Hospital, Fudan University 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