{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:49:06Z","timestamp":1740138546239,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010555","name":"The Mount Sinai Health System","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010555","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Although salvage total laryngectomy remains the definitive approach to recurrent\/persistent glottic cancer following failed radiation therapy for favorable early\u2010stage disease, it comes at the price of a permanent laryngostome and an impact on quality of life. We describe a three\u2010stage method of laryngeal reconstruction for salvage partial laryngectomy to address the unique challenges of operating on radiation recurrent\/persistent cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>This was a single\u2010surgeon retrospective case series of patients who underwent a three\u2010stage laryngeal reconstruction for salvage partial laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a comprehensive review of the clinical, pathologic, and radiologic files of all patients who underwent a three\u2010stage laryngeal reconstruction for salvage partial laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven male patients underwent a three\u2010stage laryngeal reconstruction following open partial salvage laryngectomy. The average follow\u2010up time since salvage surgery was 55 months. All patients were without evidence of recurrence and demonstrated satisfactory functional outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Staged reconstruction provides a more controlled assessment of wound healing and valuable pathologic information regarding the specific disease virulence and adequacy of the margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 126:1061\u20131070, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25593","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T09:55:14Z","timestamp":1446803714000},"page":"1061-1070","source":"Crossref","is-referenced-by-count":2,"title":["Staged laryngeal reconstruction with a prefabricated flap for radiation recurrent glottic carcinoma"],"prefix":"10.1002","volume":"126","author":[{"given":"Moustafa W.","family":"Mourad","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai Beth Israel New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry K.","family":"Su","sequence":"additional","affiliation":[{"name":"the Thyroid, Head and Neck Cancer (THANC) Foundation New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry R.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai Beth Israel New York New York U.S.A."},{"name":"the Thyroid, Head and Neck Cancer (THANC) Foundation New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy L.","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai Beth Israel New York New York U.S.A."},{"name":"the Thyroid, Head and Neck Cancer (THANC) Foundation New York New York U.S.A."},{"name":"Department of Otolaryngology Icahn School of Medicine at Mount Sinai New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason B.","family":"Clain","sequence":"additional","affiliation":[{"name":"the Thyroid, Head and Neck Cancer (THANC) Foundation New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline S.","family":"Mojica","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai Beth Israel New York New York U.S.A."},{"name":"the Thyroid, Head and Neck Cancer (THANC) Foundation New York New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Urken","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai Beth Israel New York New York U.S.A."},{"name":"the Thyroid, Head and Neck 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