{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:36:13Z","timestamp":1785281773142,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Squamous cell carcinoma (SCC) accounts for\u2009&gt;\u200990% of head and neck cancers and 60% to 75% of malignancies of the paranasal sinuses. The most commonly affected paranasal sinus is the maxillary. Epidemiologic, incidence, and survival trends have been studied for maxillary sinus SCC (MSSCC), but far less is known about its metastatic potential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective database analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Surveillance, Epidemiology, and End Results database was used to extract frequency, incidence, and survival data for MSSCC between 2004 and 2012. The resultant cases were stratified according to patient demographics and collaborative stage information, including extent of disease, lymph node involvement, TNM staging, and regional and distant metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 854 cases of MSSCC were identified. The mean age at diagnosis was 66.6 years, with 87.4% presenting at\u2009&gt;\u200950 years. Most patients (65.1%) were male. Whites accounted for 74.6% of cases. A majority (64.3%) of cases presented with stage IV disease. Overall 5\u2010year disease\u2010specific survival was 23.4%. Neck involvement was seen in 7.6% of T1 tumors, 22.2% of T2 tumors, 18.5% of T3 tumors, and 12.2% of T4 tumors. Distant metastasis was not seen in T1\u2013T3 tumors, but was present in 6.8% of T4 tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MSSCC is a rare entity with poor overall prognosis. The majority of patients included in this study were white males aged \u226550 years, with most tumors presenting at advanced stages. Nodal involvement and distant metastasis are poor prognostic indicators. T1\u2013T3 tumors did not metastasize to distant sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 126:399\u2013404, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25601","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T21:27:45Z","timestamp":1442957265000},"page":"399-404","source":"Crossref","is-referenced-by-count":66,"title":["Squamous cell carcinoma of the maxillary sinus: A population\u2010based analysis"],"prefix":"10.1002","volume":"126","author":[{"given":"Pariket M.","family":"Dubal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Bhojwani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Facial Plastic Surgery Rowan University School of Osteopathic Medicine Stratford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan D.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omry","family":"Zuckerman","sequence":"additional","affiliation":[{"name":"Rowan University School of Osteopathic Medicine Stratford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School Newark"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey, Rutgers New Jersey Medical School Newark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head 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