{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:14:00Z","timestamp":1781295240502,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To identify variations in surgical technique that impact the recurrence of inverted papilloma following endoscopic excision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 127 consecutive patients who underwent endoscopic excision of inverted papilloma and oncocytic papilloma at a tertiary care medical center from 1998 to 2011 were reviewed. Patient demographics, comorbidities, tumor stage, and intraoperative details, including tumor location and management of the base, were evaluated to identify factors associated with tumor recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recurrence of papilloma occurred in 16 patients (12.6%). Mean time to recurrence was 31.0 months (range, 5.2\u2013110.0 months). Mucosal stripping alone was associated with a recurrence rate of 52.2% (12\/23 patients), compared to 4.9% (3\/61 patients) when the tumor base was drilled, 4.7% (1\/21 patients) when it was cauterized, and 0.0% (0\/22 patients) when it was completely excised (<jats:italic>P<\/jats:italic> = .001). Increased recurrence rate was associated with tumors located in the maxillary sinus (<jats:italic>P<\/jats:italic> = .03), as well as the performance of endoscopic medial maxillectomy (<jats:italic>P<\/jats:italic> = .001) and external frontal approaches (<jats:italic>P<\/jats:italic> = .02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Drilling, cauterizing, or completely excising the bone underlying the tumor base during endoscopic resection reduces the recurrence rate of inverted and oncocytic papilloma, when compared to mucosal stripping alone. Surgeons who perform endoscopic resection of these tumors should consider utilization of these techniques when possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 126:796\u2013801, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25663","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T13:20:25Z","timestamp":1442323225000},"page":"796-801","source":"Crossref","is-referenced-by-count":64,"title":["Surgical risk factors for recurrence of inverted papilloma"],"prefix":"10.1002","volume":"126","author":[{"suffix":"Jr.","given":"David Y.","family":"Healy","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Naval Medical Center Portsmouth Portsmouth Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipun","family":"Chhabra","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Illinois College of Medicine, Saint Anthony Medical Center Rockford Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Metson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts"},{"name":"Department of Otology and Laryngology Harvard Medical School Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric H.","family":"Holbrook","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts"},{"name":"Department of Otology and Laryngology Harvard Medical School Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey T.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts"},{"name":"Department of Otology and Laryngology Harvard Medical School Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110000599"},{"key":"e_1_2_6_3_1","first-page":"28","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetic of Head and Neck Tumours","author":"Barnes L","year":"2005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2006.01333.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.11.038"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23275"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1365-2273.2000.00357.x","article-title":"Recurrence and malignant degeneration of 89 cases of inverted papilloma diagnosed in a non\u2010tertiary referral population between 1975 and 1995: clinical predictors and p53 studies","volume":"25","author":"Jardine AH","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500312554"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948609500301"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000230401.88711.e6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23275"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20042"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200006000-00015"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200108000-00015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31803330f1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198711000-00004"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25663","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T01:40:11Z","timestamp":1696556411000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,15]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/lary.25663"],"URL":"https:\/\/doi.org\/10.1002\/lary.25663","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,15]]}}}