{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:29:34Z","timestamp":1769639374263,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T00:00:00Z","timestamp":1444003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001349","name":"The National Medical Research Council","doi-asserted-by":"crossref","award":["(NMRC, IRG10may086, CIRG12Nov033)"],"award-info":[{"award-number":["(NMRC, IRG10may086, CIRG12Nov033)"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Singapore Immunology Network","award":["(SIgN, SIgN 10-028)"],"award-info":[{"award-number":["(SIgN, SIgN 10-028)"]}]},{"DOI":"10.13039\/501100001809","name":"The National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["(81170897, 81441028)"],"award-info":[{"award-number":["(81170897, 81441028)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Nasal inverted papilloma (IP) is a benign tumor with high recurrence rates. Evidence of inflammation has been reported in IP in Caucasian studies. This study aimed to investigate the histopathological patterns and their associations with clinical characteristics in Chinese patients with IP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Basic science study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IP tissues were obtained from 50 Chinese patients with unilateral IPs. Biopsies of inferior turbinate mucosa from 17 healthy subjects were used as controls. The histological patterns and severity of epithelial remodeling and inflammatory cell infiltration were evaluated and analyzed for associations with clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one percent of IP specimens were classified as grade I (mild remodeling) and 49% as grade II (moderate and severe remodeling). Concomitant inflammatory nasal polyps were found in 14 patients (28%). Recurrent IP was strongly associated with grade II (odds ratio: 5.81, 95% confidence interval: 1.34\u201025.18). Except CD4<jats:sup>+<\/jats:sup> T cells, quantities of neutrophils, macrophages, eosinophils, CD8<jats:sup>+<\/jats:sup> T cells, and FoxP3<jats:sup>+<\/jats:sup> T\u2010reg cells were significantly elevated in IP. Of these, neutrophils were the predominant cell type in IP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inflammation may have potential roles in IPs and the higher grade of epithelial remodeling was associated with the recurrence of IPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 126:E141\u2013E147, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25694","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T10:26:51Z","timestamp":1444040811000},"source":"Crossref","is-referenced-by-count":26,"title":["Histopathological features of sinonasal inverted papillomas in chinese patients"],"prefix":"10.1002","volume":"126","author":[{"given":"Li","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology , The Second Affiliated Hospital Shandong University Shandong China"},{"name":"Key Research Laboratory of Otolaryngology , National Health and Family Planning Commission of China Shandong University Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , National University of Singapore National University Health System  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , The Second Affiliated Hospital Shandong University Shandong China"},{"name":"Key Research Laboratory of Otolaryngology , National Health and Family Planning Commission of China Shandong University Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chew Lip","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , National University of Singapore National University Health System  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi Bin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Medical Hospital of Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , National University of Singapore National University Health System  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The First Affiliated Medical Hospital of Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt Fredrik","family":"Petersson","sequence":"additional","affiliation":[{"name":"Department of Pathology , National University of Singapore National University Health 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