{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:58:43Z","timestamp":1769641123825,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Agency of Zhejiang Province","award":["2013C33176"],"award-info":[{"award-number":["2013C33176"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>We evaluated the effects of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on the healing of large traumatic tympanic membrane perforations (TMPs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, prospective analysis was performed between June 2013 and August 2014 on the treatment of traumatic TMPs larger than 25% of the TM. Closure rate, closure time, hearing gain, and rate of otorrhea were compared between EGF and bFGF groups, as well as to an observation\u2010only group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Final analysis was performed on 86 patients at 3 months. The closure rates of perforation in the EGF, bFGF, and observation groups were 86.2%, 89.3%, and 72.4%, respectively. The closure rates in the EGF and bFGF groups were 14% to 17% higher than in the observation group, although the difference was not statistically significant for the total closure rate among the three groups (<jats:italic>P<\/jats:italic> = 0.200). The average closure time was significantly longer (<jats:italic>P<\/jats:italic> &lt; 0.01) in the observation group than in the EGF and bFGF groups. However, the closure times in the EGF and bFGF groups were not significantly different (<jats:italic>P<\/jats:italic> = 0.92). In addition, differences in purulent otorrhea rates among the groups were not statistically significant (<jats:italic>P<\/jats:italic> = 0.82).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both EGF and bFGF can accelerate the closure of human large traumatic TMPs. The healing outcomes among the two growth factors were not significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b. <jats:italic>Laryngoscope<\/jats:italic>, 126:E23\u2013E28, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25715","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T14:08:46Z","timestamp":1444399726000},"source":"Crossref","is-referenced-by-count":38,"title":["Comparative study on the effects of <scp>EGF<\/scp> and b<scp>FGF<\/scp> on the healing of human large traumatic perforations of the tympanic membrane"],"prefix":"10.1002","volume":"126","author":[{"family":"Zhengcai\u2010Lou","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology The Affiliated YiWu Hospital of Wenzhou Medical University Zhejiang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Zihan\u2010Lou","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Xinxiang Medical University Henan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Yongmei\u2010Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology The Affiliated YiWu Hospital of Wenzhou Medical University Zhejiang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"642","article-title":"Tympanoplasty after war blast lesions of the eardrum: retrospective study","volume":"42","author":"Sprem N","year":"2001","journal-title":"Croat Med 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