{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:39:25Z","timestamp":1787614765400,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Center for Advancing Translational Sciences (NCATS, NIH) Clinical and Translational Science Award (CTSA)","award":["UL1 TR000043"],"award-info":[{"award-number":["UL1 TR000043"]}]},{"name":"Anderson Cancer Research Center at The Rockefeller University"},{"name":"Pershing Square Sohn Cancer Research Prize"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To describe the management and outcomes of Fanconi anemia (FA) patients with head and neck squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic information, prognostic factors, therapeutic management, and survival outcomes for FA patients enrolled in the International Fanconi Anemia Registry who developed head and neck squamous cell carcinoma (HNSCC) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five FA patients were diagnosed with HNSCC at a mean age of 32 years. The most common site of primary cancer was the oral cavity (26 of 35, 74%). Thirty patients underwent surgical resection of the cancer. Sixteen patients received radiation therapy with an average radiation dose of 5,050 cGy. The most common toxicities were high\u2010grade mucositis (9 of 16, 56%), hematologic abnormalities (8 of 16, 50%), and dysphagia (8 of 16, 50%). Three patients received conventional chemotherapy and had significant complications, whereas three patients who received targeted chemotherapy with cetuximab had fewer toxicities. The 5\u2010year overall survival rate was 39%, with a cause\u2010specific survival rate of 47%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fanconi anemia patients have a high risk of developing aggressive HNSCC at an early age. Fanconi anemia patients can tolerate complex ablative and reconstructive surgeries, but careful postoperative care is required to reduce morbidity. The treatment of FA\u2010associated HNSCC is difficult secondary to the poor tolerance of radiation and chemotherapy. However, radiation should be used for high\u2010risk cancers due to the poor survival in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 126:870\u2013879, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25726","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T23:05:22Z","timestamp":1445468722000},"page":"870-879","source":"Crossref","is-referenced-by-count":95,"title":["Natural history and management of <scp>F<\/scp>anconi anemia patients with head and neck cancer: A 10\u2010year follow\u2010up"],"prefix":"10.1002","volume":"126","author":[{"given":"David I.","family":"Kutler","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery New York Presbyterian Hospital\/Weill Cornell Medical College New York New York U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krupa 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