{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T07:12:32Z","timestamp":1781680352106,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Sulcus vocalis is an epithelial invagination adherent to deep tissues of the vocal fold. Traditionally, dysphonia is believed to result from attenuation or absence of lamina propria and consequent alteration of mucosal dynamics. This conception does not account for several clinical features of the lesion, most notably inflammation. The goal of this study is to elucidate the clinical nature of sulcus by re\u2010examination of its histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical features, including stroboscopic examination, and hematoxylin and eosin sections of 19 lesions in 15 patients who underwent surgery were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Epithelial change was found uniformly in all specimens, consisting of parakeratosis (78.9%), epithelial thickening (77.8%), dyskeratosis (63.2%), basement membrane thickening (47%), epithelial inflammation (52.6%), and retention of keratin debris (36.8%). In contrast, submucosal findings were less prevalent. Seven patients (36.8%) had essentially normal subepithelial tissues. Submucosal inflammation was present in seven (36.8%), and other submucosal changes in four of 17 (23.5%). Clinical characteristics demonstrated general improvement after surgical intervention in most cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sulcus vocalis appears to have an important component of epithelial pathology, with especially high prevalence of parakeratosis, dyskeratosis, and epithelial thickening. Clinical changes may result from prominent perilesional inflammation related to epithelial changes instead of or in addition to any alteration of the lamina propria. Surgical treatment, when necessary, should refocus on removal of pathologic epithelium as a source of inflammation independent of reconstructive considerations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<jats:italic>Laryngoscope<\/jats:italic>, 126:1397\u20131403, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25732","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T11:34:50Z","timestamp":1446550490000},"page":"1397-1403","source":"Crossref","is-referenced-by-count":34,"title":["Sulcus vocalis: A new clinical paradigm based on a re\u2010evaluation of histology"],"prefix":"10.1002","volume":"126","author":[{"given":"Andrew","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian","family":"Sulica","sequence":"additional","affiliation":[{"name":"the Sean Parker Institute for the Voice, Department of Otolaryngology\u2013Head &amp; Neck Surgery, Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana","family":"Aylward","sequence":"additional","affiliation":[{"name":"College of Physicians &amp; Surgeons, Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Scognamiglio","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1288\/00005537-195802000-00006","article-title":"Dysplasia dysphonia: minor anomalies of the vocal folds causing persistent hoarseness","volume":"68","author":"Arnold GE","year":"1958","journal-title":"Laryngoscope"},{"issue":"9","key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1288\/00005537-198509000-00014","article-title":"Epidermoid cysts, sulci, and mucosal bridges of the true vocal cord: a report of 157 cases","volume":"95","author":"Bouchayer M","year":"1985","journal-title":"Laryngoscope"},{"issue":"1","key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1288\/00005537-199401000-00005","article-title":"Sulcus vocalis in laryngeal cancer: a histopathologic study","volume":"104","author":"Nakayama M","year":"1994","journal-title":"Laryngoscope"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949610500304"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900901"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0230-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900206"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.05.059"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100307"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411300504"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200406000-00028"},{"key":"e_1_2_6_13_1","first-page":"303","volume-title":"Textbook of Laryngology","author":"Anderson TD","year":"2007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811404639"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050000254"},{"key":"e_1_2_6_16_1","first-page":"819","article-title":"Clinical and pathological investigations of sulcus vocalis","volume":"22","author":"Shin Y","year":"1976","journal-title":"Otologia (Fukuoka)"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700111"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24890"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(05)80260-7"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25732","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T05:46:48Z","timestamp":1718171208000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,3]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/lary.25732"],"URL":"https:\/\/doi.org\/10.1002\/lary.25732","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,3]]}}}