{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:03:49Z","timestamp":1788829429715,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Anterior commissure involvement is considered to be a risk factor for poorer outcomes after transoral laser cordectomy (TLC) for early glottic cancer. The objective of this study was to determine the outcomes and relevance of the tumor\u2010node\u2010metastasis (TNM) classification in a large series of patients with early glottic cancer involving the anterior commissure treated by TLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical and surgical parameters, as well as follow\u2010up results, of the patients treated consecutively for early\u2010stage glottic squamous cell carcinoma involving the anterior commissure (Tis, T1a, T1b, and T2) by transoral CO2 laser cordectomy in an urban academic medical center from January 2001 to March 2013 were analyzed retrospectively.<\/jats:p><jats:p>The main outcomes measures were: 5\u2010year disease free survival (DFS), ultimate local control with laser alone, laryngeal preservation, overall\u2010survival (OS) rates, and disease\u2010specific survival (DSS) rates (Kaplan\u2010Meier).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010six patients treated from January 2001 to March 2013 were included. The 5\u2010year DFS and ultimate local control with laser alone rates were 61.7% and 74.4%, respectively. The laryngeal preservation rate was 93.4%; and the OS and DSS rates were 79.2% and 91.5%, respectively. Postoperative T classification (pT) status was not found to be a significant predictor of recurrences, but was predictive of more severe recurrences requiring other treatments than laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TLC is an effective treatment for early stage glottic cancer involving the anterior commissure. The TNM classification is a relevant prognosis factor for severe recurrences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 126:1817\u20131822, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25757","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T07:33:24Z","timestamp":1448350404000},"page":"1817-1822","source":"Crossref","is-referenced-by-count":67,"title":["Early glottic cancer involving the anterior commissure treated by transoral laser cordectomy"],"prefix":"10.1002","volume":"126","author":[{"given":"Caroline","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Cornu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck 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