{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:19:37Z","timestamp":1779898777073,"version":"3.53.1"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The goal of this systematic review was to compare the efficacy and ototoxicity of Locacorten\u2010Vioform (Paladin Labs Inc., Montreal, Quebec, Canada) and clotrimazole in the treatment of patients with otomycosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Embase, Cumulative Index to Nursing and Allied Health Literature, MEDLINE, World Health Organization International Clinical Trials Registry Platform, European Union Clinical Trials Register, Cochrane Library databases of clinical trials, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included any randomized controlled trials or nonrandomized studies (case\u2010control, cohort, and case series) assessing the topical use of Locacorten\u2010Vioform (Paladin Labs Inc.) and\/or clotrimazole in adult and\/or pediatric immunocompetent patient population with otomycosis. DerSimonian and Laird's random effects approach was used for meta\u2010analysis, followed by an assessment of heterogeneity and subgroup analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 226 reviewed articles, 14 were retained. Clotrimazole efficacy rate was 85% (95% confidence interval [CI]: 79.7\u201389.0%), whereas Locacorten\u2010Vioform (Paladin Labs Inc.) was 73% (95% CI: 56.0\u201384.5%). Overall, study quality was low. There was high heterogeneity in both groups (I<jats:sup>2<\/jats:sup> of 47 and 49). There were only three studies assessing Locacorten\u2010Vioform (Paladin Labs Inc.); therefore, comparative assessment was not possible. A one\u2010way meta\u2010analysis involving 13 clotrimazole studies was performed. Heterogeneity across studies was high; however, studies using objective analysis assessing treatment efficacy, randomized controlled trials, studies using drops, studies performed in Asia, and studies where <jats:italic>Candida<\/jats:italic> was the major fungus at diagnosis demonstrated low heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although both are safe and effective, there is insufficient evidence supporting increased efficacy of either clotrimazole or Locacorten\u2010Vioform (Paladin Labs Inc.) for the treatment of otomycosis. High\u2010quality comparative studies are required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>N\/A. <jats:italic>Laryngoscope<\/jats:italic>, 126:1411\u20131419, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25761","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T14:17:34Z","timestamp":1448374654000},"page":"1411-1419","source":"Crossref","is-referenced-by-count":20,"title":["A comparison of <scp>L<\/scp>ocacorten\u2010<scp>V<\/scp>ioform and clotrimazole in otomycosis: A systematic review and one\u2010way meta\u2010analysis"],"prefix":"10.1002","volume":"126","author":[{"given":"Khrystyna","family":"Herasym","sequence":"first","affiliation":[{"name":"Department of Medicine University of Ottawa Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Bonaparte","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Ottawa Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun","family":"Kilty","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Ottawa Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510009678X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.07.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200004000-00003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23718"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488109133235"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988910000209"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(89)90032-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(88)80041-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1978.tb13212.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1975.tb106157.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(80)80020-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200112000-00004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894900990S612"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1983.00800240043008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(88)80001-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488909107401"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.12.003"},{"key":"e_1_2_7_19_1","volume-title":"Anti\u2010Infective Guidelines for Community\u2010Acquired Infections","author":"Anti\u2010Infective Review Panel","year":"2013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1969.tb92123.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100056917"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198811000-00005"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197811000-00005"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.12.005"},{"key":"e_1_2_7_25_1","first-page":"927","article-title":"Otitis externa: a practical guide to treatment and prevention","volume":"63","author":"Sander R","year":"2001","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_26_1","unstructured":"Preferred Reporting for Systematic Reviews and Meta\u2010Analyses (PRISMA). 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