{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T12:35:05Z","timestamp":1781354105520,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>In\u2010office percutaneous injection laryngoplasty (IL) is a common treatment for glottal insufficiency. The objective of this prospective study was to determine if voice outcomes from IL are affected by age, gender, or initial disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive adult patients undergoing awake injection laryngoplasty were recruited from a subspecialty laryngology clinic. Voice Handicap Index (VHI\u201030); Consensus Auditory\u2010Perceptual Evaluation of Voice (CAPE\u2010V); and Grade, Roughness, Breathiness, Asthenia and Strain (GRBAS) Dysphonia Scale were evaluated prior to and 2 months after injection. Patients who had more severe disease were defined as those patients with greater initial perception of handicap, with a VHI score greater than 60.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five subjects were enrolled, and 27 (16 male; mean age 61.6 \u00b1 13.2 years) had complete data. No impact from age or gender was seen on outcomes from IL as measured by VHI\u201030 (<jats:italic>P<\/jats:italic> = 0.397 for age; <jats:italic>P<\/jats:italic> = 0.764 for gender), CAPE\u2010V (<jats:italic>P<\/jats:italic> = 0.675 for age, <jats:italic>P<\/jats:italic> = 0.975 for gender), or GRBAS (<jats:italic>P<\/jats:italic> = 0.213 for age, <jats:italic>P<\/jats:italic> = 0.983 for gender). Patients with poorer initial VHI tended to have more significant improvement (<jats:italic>P<\/jats:italic> = 0.002), which may represent a ceiling effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this prospective clinical study, age and gender did not affect outcome in IL. Patients with more severe disease appeared to have greater improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 126:1806\u20131809, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25764","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T07:33:24Z","timestamp":1448350404000},"page":"1806-1809","source":"Crossref","is-referenced-by-count":12,"title":["Impact of patient\u2010related factors on the outcomes of office\u2010based injection laryngoplasty"],"prefix":"10.1002","volume":"126","author":[{"given":"Maya G.","family":"Sardesai","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert L.","family":"Merati","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Drexel University College of Medicine Philadelphia Pennsylvania U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Birkent","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Gulhane Military Medical Academy Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20737"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2012.07.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941312200901"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2011.11.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21028"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813508082"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.10.028"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100103"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0603.66"},{"key":"e_1_2_7_12_1","volume-title":"Clinical Examination of Voice","author":"Hirano M","year":"1981"},{"key":"e_1_2_7_13_1","unstructured":"The American Speech\u2010Language\u2010Hearing Association (ASHA) Special Interest Division 3 Voice and Voice Disorders. 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