{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:02:09Z","timestamp":1790362929676,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scholars in Medicine Office at Harvard Medical School"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Optical coherence tomography (OCT) is a promising technology to noninvasively assess vocal fold microanatomy. The goal of this study was to develop a methodology using OCT to identify quantifiable markers of vocal fold development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>In vivo study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A two\u2010step process was developed to reproducibly image the midmembranous vocal fold edge of 10 patients younger than 2 years and 10 patients between 11 and 16 years of age using OCT. An image analysis algorithm was implemented to extract OCT\u2010derived A\u2010lines for each patient. These A\u2010lines were divided into three zones according to apparent changes in slope. Relative attenuation coefficients, or tissue\u2010 and system\u2010dependent parameters that describe the rate at which optical signal decays, were calculated for each zone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Young patients had distinct relative attenuation coefficients in zone 1 (<jats:italic>P<\/jats:italic> &lt; .0001), whereas zones 2 and 3 were indistinct (<jats:italic>P<\/jats:italic> = .1129). Older patients had distinct relative attenuation coefficients in zones 1, 2, and 3 (<jats:italic>P<\/jats:italic> &lt; .0370). Between age groups, relative attenuation coefficients were different in zones 2 and 3 (<jats:italic>P<\/jats:italic> &lt; .0001, <jats:italic>P<\/jats:italic> = .0315, respectively) and indistinct in zone 1 (<jats:italic>P<\/jats:italic> = .1438).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Relative attenuation coefficients can be used as markers of vocal fold development. Differences in relative attenuation coefficients likely represent changes in extracellular matrix structure within the lamina propria and may become useful for guiding treatment of voice disorders in the pediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 126:E218\u2013E223, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25765","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T12:11:44Z","timestamp":1446552704000},"source":"Crossref","is-referenced-by-count":19,"title":["Using attenuation coefficients from optical coherence tomography as markers of vocal fold maturation"],"prefix":"10.1002","volume":"126","author":[{"given":"Jordan A.","family":"Garcia","sequence":"first","affiliation":[{"name":"Department of Otolaryngology , Massachusetts Eye and Ear Infirmary Harvard Medical School Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouzi","family":"Benboujja","sequence":"additional","affiliation":[{"name":"Engineering Physics Department Polytechnique Montreal Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Beaudette","sequence":"additional","affiliation":[{"name":"Engineering Physics Department Polytechnique Montreal Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Boudoux","sequence":"additional","affiliation":[{"name":"Engineering Physics Department Polytechnique Montreal Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Hartnick","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0995-970"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2002.800510.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.neo.7900071"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.02005.x"},{"key":"e_1_2_6_6_1","first-page":"327","article-title":"Optical coherence tomography of the newborn airway","volume":"117","author":"Ridgway JM","year":"2008","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000181465.17744.BE"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20654"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811403078"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000217539.27432.5a"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2008.518"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JMI.2.2.026003","article-title":"Automated working distance adjustment enables optical coherence tomography of the human larynx in awake patients","volume":"2","author":"Donner S","year":"2015","journal-title":"J Med Imaging (Bellingham)"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201501-0053OC"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.11.019"},{"key":"e_1_2_6_15_1","volume-title":"Vocal Fold Physiology Contemporary Research & Clinical Issues","author":"Hirano M","year":"1983"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100103"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.88"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318159aa0d"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150685.54893.e9"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2013.07.018"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212101109"},{"key":"e_1_2_6_22_1","article-title":"Intraoperative imaging of pediatric vocal cord lesions using optical coherence tomography","author":"Benboujja F","journal-title":"J Biomed Opt."},{"key":"e_1_2_6_23_1","first-page":"1","article-title":"Design and performance of broadly tunable, narrow line\u2010width, high repetition rate 1310nm VCSELs for swept source optical coherence tomography","volume":"8726","author":"Jayaraman V","year":"2012","journal-title":"Proc SPIE"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.4.001119"},{"key":"e_1_2_6_25_1","first-page":"11","article-title":"Structure of the vocal fold in normal and disease states anatomical and physical studies","volume":"11","author":"Hirano M","year":"1981","journal-title":"ASHA Rep"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814547489"},{"key":"e_1_2_6_27_1","first-page":"657","article-title":"Mapping tissue optical attenuation to identify cancer using optical coherence tomography","volume":"12","author":"McLaughlin RA","year":"2009","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2005.854297"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3479931"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.3.000533"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.5.001217"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.18.014644"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200312000-00027"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2014.03.001"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/55\/1\/011"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.25765","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.25765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:14:08Z","timestamp":1695492848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.25765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,3]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/lary.25765"],"URL":"https:\/\/doi.org\/10.1002\/lary.25765","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,3]]}}}