{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:49:00Z","timestamp":1740138540667,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"crossref","award":["90-01-01-2815"],"award-info":[{"award-number":["90-01-01-2815"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007432","name":"Shiraz Institute for Cancer Research","doi-asserted-by":"crossref","award":["ICR-100-502"],"award-info":[{"award-number":["ICR-100-502"]}],"id":[{"id":"10.13039\/501100007432","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To investigate soluble syndecan\u20101 (Sdc\u20101) in the sera of patients with tongue squamous cell carcinoma (SCC) and its correlation with the histopathological criteria of tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>In a case\u2010control study using a convenient method of sampling, 18 female and 25 male patients with confirmed diagnosis of tongue SCC, and 19 healthy females and 27 males were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Soluble Sdc\u20101 was measured in the sera of 43 patients with tongue SCC and was compared with that of healthy age\u2010\/sex\u2010matched controls using a commercial enzyme\u2010linked immunosorbent assay. Clinical and pathological data, along with the demographic characteristics of the patients, were recorded at the time of sampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of soluble Sdc\u20101 were decreased in the sera of patients compared to controls (91.17 \u00b1 88.60 vs. 158.17 \u00b1 103.47 ng\/mL, <jats:italic>P<\/jats:italic> = .002). Although patients who smoke tended to have higher grades (<jats:italic>P<\/jats:italic> = .043), there was no significant difference in the level of syndecan\u20101 between smokers and non\u2010smokers. A significant difference between syndecan\u20101 in the sera of patients with tumors of different stages was observed (Kruskal\u2010Wallis test <jats:italic>P<\/jats:italic>=0.039); however, scarcity of patients in stages I and III decreased the power of the comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sdc\u20101 levels in the sera of patients do not correlate with the tumor progression in the tongue SCC. This is in contrast with the reported inverse correlation between the expression level of membranous Sdc\u20101 and the histological grade and size of head and neck tumors. Therefore, Sdc\u20101 shedding may not be a major mechanism in the progressive loss of its expression regarding tongue tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 126:E191\u2013E195, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25812","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T10:39:43Z","timestamp":1450175983000},"source":"Crossref","is-referenced-by-count":6,"title":["Reduced serum levels of syndecan\u20101 in patients with tongue squamous cell carcinoma"],"prefix":"10.1002","volume":"126","author":[{"given":"Mohammad Sohrabi","family":"Shegefti","sequence":"first","affiliation":[{"name":"Department of Immunology , School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahyar","family":"Malekzadeh","sequence":"additional","affiliation":[{"name":"Institute for Cancer 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