{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:37:11Z","timestamp":1783093031646,"version":"3.54.6"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To determine if apnea\u2010hypopnea index (AHI) and lowest oxygen saturation (LSAT) improve following isolated supraglottoplasty for laryngomalacia with obstructive sleep apnea (OSA) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Systematic review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine databases, including PubMed\/MEDLINE, were searched through September 30, 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 517 studies were screened; 57 were reviewed; and 13 met criteria. One hundred thirty\u2010eight patients were included (age range: 1 month\u201312.6 years). Sixty\u2010four patients had sleep exclusive laryngomalacia, and in these patients: 1) AHI decreased from a mean (M) \u00b1 standard deviation (SD) of 14.0 \u00b1 16.5 (95% confidence interval [CI] 10.0, 18.0) to 3.3 \u00b1 4.0 (95% CI 2.4, 4.4) events\/hour (relative reduction: 76.4% [95% CI 53.6, 106.4]); 2) LSAT improved from a M \u00b1 SD of 84.8 \u00b1 8.4% (95% CI 82.8, 86.8) to 87.6 \u00b1 4.4% (95% CI 86.6, 88.8); 3) standardized mean differences (SMD) demonstrated a small effect for LSAT and a large effect for AHI; and 4) cure (AHI &lt; 1 event\/hour) was 10.5% (19 patients with individual data). Seventy\u2010four patients had congenital laryngomalacia, and in these patients: 1) AHI decreased from a M \u00b1 SD of 20.4 \u00b1 23.9 (95% CI 12.8, 28.0) to 4.0 \u00b1 4.5 (95% CI 2.6, 5.4) events\/hour (relative reduction: 80.4% [95% CI 46.6, 107.4]); 2) LSAT improved from a M \u00b1 SD of 74.5 \u00b1 11.9% (95% CI 70.9, 78.1) to 88.4 \u00b1 6.6% (95% CI 86.4, 90.4); 3) SMD demonstrated a large effect for both AHI and LSAT; and 4) cure was 26.5% (38 patients with individual data).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Supraglottoplasty has improved AHI and LSAT in children with OSA and either sleep exclusive laryngomalacia or congenital laryngomalacia; however, the majority of them are not cured. <jats:italic>Laryngoscope<\/jats:italic>, 126:1246\u20131255, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25827","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T11:56:50Z","timestamp":1450785410000},"page":"1246-1255","source":"Crossref","is-referenced-by-count":74,"title":["Supraglottoplasty for laryngomalacia with obstructive sleep apnea: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"126","author":[{"given":"Macario","family":"Camacho","sequence":"first","affiliation":[{"name":"Otolaryngology\u2013Head and Neck Surgery, Division of Sleep Surgery and Medicine Tripler Army Medical Center Honolulu Hawaii"},{"name":"Department of Psychiatry and Behavioral Sciences, Sleep Medicine Division, Stanford Hospital and Clinics Stanford Hospital and Clinics Stanford California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandyn","family":"Dunn","sequence":"additional","affiliation":[{"name":"John A. Burns School of Medicine University of Hawaii Honolulu Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Torre","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Sleep Surgery Stanford Hospital and Clinics Stanford California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Sasaki","sequence":"additional","affiliation":[{"name":"John A. Burns School of Medicine University of Hawaii Honolulu Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\/Sleep Medicine Centre\u2013Hospital CUF University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley Yung\u2010Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Pediatric Otolaryngology University of California San Francisco San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan K.","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Medicine Uniformed Services University of the Health Sciences Bethesda Maryland 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