{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:50:54Z","timestamp":1783032654614,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Trigeminal sensation (TS) within the nasal cavity is important for the perception of nasal airflow. The objective of this study is to examine whether impaired TS contributes to the sensation of nasal obstruction in patients with chronic rhinosinusitis (CRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective case\u2010control study conducted in a tertiary referral rhinology clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases consisted of CRS patients with subjective nasal obstruction, not previously treated with oral corticoids. Controls consisted of patients without CRS. Neither group demonstrated obvious anatomical obstructions. Both groups underwent peak nasal inspiratory flows (PNIF), olfactory testing (quick eight\u2010item odor identification test), and trigeminal testing (lateralization task using eucalyptol and odorless solvent).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 28 subjects (14 CRS patients and 14 controls) were recruited. Analyses revealed no statistical differences in age (<jats:italic>P<\/jats:italic> = .93), gender (<jats:italic>P<\/jats:italic> = .47), or PNIF (<jats:italic>P<\/jats:italic> = .82) between the two groups, but they differed in Lund\u2010Mackay scores (<jats:italic>P<\/jats:italic> &lt; .001). There was no significant difference in olfactory testing (<jats:italic>P<\/jats:italic> = .15). CRS patients had significantly lower scores on trigeminal lateralization testing than controls (<jats:italic>P<\/jats:italic> = .007). Linear regression revealed that Lund\u2010Mackay scores contributed a significant amount of variance to trigeminal lateralization scores, controlling for age and sex (<jats:italic>F<\/jats:italic> = 5.93, <jats:italic>P<\/jats:italic> = .004, <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.43).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to demonstrate that patients with CRS have lower TS than healthy controls. Our results suggest defective TS could play a role in the sensation of nasal obstruction in CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3b. <jats:italic>Laryngoscope<\/jats:italic>, 126:E174\u2013E178, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25952","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T05:33:39Z","timestamp":1456810419000},"source":"Crossref","is-referenced-by-count":31,"title":["The role of trigeminal function in the sensation of nasal obstruction in chronic rhinosinusitis"],"prefix":"10.1002","volume":"126","author":[{"given":"Joe","family":"Saliba","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naif","family":"Fnais","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery McGill University Montreal Quebec Canada"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Tomaszewski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junie S.","family":"Carriere","sequence":"additional","affiliation":[{"name":"Department of Psychology McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul","family":"Frenkiel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Frasnelli","sequence":"additional","affiliation":[{"name":"Research Chair for Chemosensory Neuroanatomy, Department of Anatomy University of Quebec in Trois\u2010Rivi\u00e8res Trois\u2010Rivi\u00e8res Quebec Canada"},{"name":"Center for Advanced Research in Sleep Medicine Sacr\u00e9\u2010Coeur Hospital Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Tewfik","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"S99","article-title":"Canadian clinical practice guidelines for acute and chronic rhinosinusitis","volume":"40","author":"Desrosiers M","year":"2011","journal-title":"J Otolaryngol Head Neck 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