{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:32:07Z","timestamp":1781796727214,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T00:00:00Z","timestamp":1460592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate the clinical features of audiologic impairment and its relationship with the nasal, vestibular, and rheumatologic profile in a cohort of patients with eosinophilic granulomatosis with polyangiitis (EGPA), formerly named Churg\u2010Strauss syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010nine patients with EGPA, considered controlled according to the Birmingham Vasculitis Activity Score and the Vasculitis Damage Index, underwent a complete audiologic evalutaion with otomicroscopy, impedance audiometry, speech audiometry, and auditory brainstem responses; rhinologic evaluation was made by means of fiberoptic endoscopy and nasal cytology; the clinical evaluation was completed with analysis of the facial function and, in patients with referred vertigo, with videonystagmography (VNG). Data were compared to the rheumatologic profile (eosinophil count, antineutrophil cytoplasmic antibodies status).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four of 39 patients fulfilled the inclusion criteria. Of those, 18 (52, 8%) were affected by variable degrees of hearing loss (sensorineural hearing loss [SNHL]) in four cases (11, 8%), mixed sensorineural and conductive hearing loss in two (5, 9%), presbycusis in six (17, 6%), and otitis media with effusion (OME) in six (17, 6%). Vestibular impairment was represented by benign paroxysmal positional vertigo and unspecific dizziness in three (8, 8%) and four cases (11, 8%), respectively, all with normal VNG. Ear involvement was statistically related to the EGPA vasculitic pattern and independent from the nasal impairment, cytology, and duration of nasal symptoms. No facial palsy was registered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our experience, the largest in the existing literature, the otological involvement in EGPA is common and may occur variably as SNHL or OME. Otological involvement occurs early in the course of the disease process, but is nonspecific in making the diagnosis of EGPA. Its recognition is therefore fundamental.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 126:2792\u20132797, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25964","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T05:20:49Z","timestamp":1460611249000},"page":"2792-2797","source":"Crossref","is-referenced-by-count":35,"title":["Focus on audiologic impairment in eosinophilic granulomatosis with polyangiitis"],"prefix":"10.1002","volume":"126","author":[{"given":"Veronica","family":"Seccia","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Unit Department of Neuroscience Azienda Ospedaliero\u2013Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Fortunato","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Department of Neuroscience Azienda Ospedaliero\u2013Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lodovica","family":"Cristofani\u2010Mencacci","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Department of Neuroscience Azienda Ospedaliero\u2013Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Dallan","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Department of Neuroscience Azienda Ospedaliero\u2013Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto P.","family":"Casani","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Department of Neuroscience Azienda Ospedaliero\u2013Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Latorre","sequence":"additional","affiliation":[{"name":"Respiratory Pathophysiology Unit Cardio\u2010Thoracic and Vascular Department Azienda Ospedaliero\u2013Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Paggiaro","sequence":"additional","affiliation":[{"name":"Respiratory Pathophysiology Unit Cardio\u2010Thoracic and Vascular Department Azienda Ospedaliero\u2013Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Bartoli","sequence":"additional","affiliation":[{"name":"Respiratory Pathophysiology Unit Cardio\u2010Thoracic and Vascular Department Azienda Ospedaliero\u2013Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Sellari\u2010Franceschini","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit Department of Neuroscience Azienda Ospedaliero\u2013Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Baldini","sequence":"additional","affiliation":[{"name":"Rheumatology Unit University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330806"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2009.02.004"},{"key":"e_1_2_7_4_1","first-page":"181","article-title":"Nasal\u2010sinus polyposis: clinical\u2010cytological grading and prognostic index of relapse","volume":"23","author":"Gelardi M","year":"2009","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12088"},{"key":"e_1_2_7_6_1","first-page":"185","article-title":"Churg\u2010Strauss syndrome with severe polyradiculoneuropathy and unilateral nerve deafness","volume":"32","author":"Heeg JE","year":"1988","journal-title":"Neth J Med"},{"key":"e_1_2_7_7_1","unstructured":"MarzoS.Churg\u2010Strauss syndrome manifesting with otological findings. 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