{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:08:56Z","timestamp":1788919736995,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:00:00Z","timestamp":1464134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate short\u2010 and long\u2010term treatment outcomes of amitriptyline for idiopathic cough.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective chart review and anonymous survey of a patient cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated a cohort of adults treated for cough at the Duke Voice Care Center with amitriptyline over a 2\u2010 to 3\u2010year period. We characterized demographics, symptoms, treatment variability, and treatment effects from chart review and survey responses. We performed univariate analysis comparing cough improvement to age, gender, symptoms of throat irritation, cough duration, concurrent speech therapy, and dosage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010nine percent were taking the medication at the first clinical follow\u2010up at a mean 2.6 months, and overall, 67% reported \u226550% improvement. No statistically significant predictors of cough improvement with medication were identified. At follow\u2010up 2 to 3 years later, overall, 53% reported \u226550% improvement, with only 34% of patients still taking amitriptyline. After 2 to 3 years, 65% of patients had titrated the medication to effect, and 33% restarted the medication. Occurrence of side effects was the most frequent reason for stopping the medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Amitriptyline can be an effective and well\u2010tolerated part of short\u2010 and long\u2010term management of idiopathic cough in adults. Titrating the dose and restarting are often necessary. Larger studies and randomized control trials are needed to better understand the outcomes of using amitriptyline to treat idiopathic cough.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 126:2758\u20132763, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25978","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T19:31:47Z","timestamp":1464204707000},"page":"2758-2763","source":"Crossref","is-referenced-by-count":46,"title":["Long\u2010term follow\u2010up of amitriptyline treatment for idiopathic cough"],"prefix":"10.1002","volume":"126","author":[{"given":"Marisa A.","family":"Ryan","sequence":"first","affiliation":[{"name":"Department of Surgery Duke Voice Care Center, Division of Head and Neck Surgery &amp; Communication Sciences, Duke University Medical Center Durham North Carolina U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth M.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Surgery Duke Voice Care Center, Division of Head and Neck Surgery &amp; Communication Sciences, Duke University Medical Center Durham North Carolina U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.1.20"},{"key":"e_1_2_7_3_1","unstructured":"Centers for Disease Control and Prevention.National Ambulatory Medical Care Survey: 2012 state and national summary tables. Available at:http:\/\/www.cdc.gov\/nchs\/data\/ahcd\/namcs_summary\/2012_namcs_web_tables.pdf. 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